Electric Literature of 5020-41-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5020-41-7, name is 2-(3-Methoxyphenyl)ethanol. A new synthetic method of this compound is introduced below.
General procedure: Alcohol S1 (2.0 mmol, 1.0 equiv) and H2SO4 (0.2 equiv) were added successively to a solution of aldehyde S2 (1.2 equiv) intoluene (5.0 mL). The reaction mixture was stirred at room temperature for 2 h. Then the reaction mixture was quenched withwater (2.0 mL) and extracted with ethyl acetate. The combined organic extract was washed with saturated brine and dried withanhydrous MgSO4. After filtration and concentration, the residue was purified by flash chromatography to give substrate 1.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,5020-41-7, 2-(3-Methoxyphenyl)ethanol, and friends who are interested can also refer to it.
Reference:
Article; Wang, Zehua; Mao, Ying; Guan, Honghao; Cao, Min; Hua, Jing; Feng, Lei; Liu, Lei; Chinese Chemical Letters; vol. 30; 6; (2019); p. 1241 – 1243;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts