As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 311-86-4, name is 2-Bromo-3,3,3-trifluoropropan-1-ol, molecular formula is C3H4BrF3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 2-Bromo-3,3,3-trifluoropropan-1-ol
2-bromo-1 ,1 , 1-trifluoropropan-3-ol (10 g, 0.0524mol) was placed in a 2-necked round bottom flask fitted with a distillation set up and then heated to 95 C. Sodium hydroxide (3 g, 0.0754 mol) was dissolved in water (12 g) at 0 C with stirring. Once the solution was homogenous it was then added dropwise to the 2-bromo-1 ,1 , 1-trifluoropropan-3-ol with rapid stirring via dropping funnel. As the head temperature reached 60 C clear liquid was collected in a receiver flask (4.2 g). GC area%: 1 , 1 , 1-trifluoro-1 ,2- epoxypropane (52%), 2-bromo-3,3,3-trifluoropropene + ethyl ether (26%), 3-acetoxy-2- bromo-1 , 1 , 1-trifluoropropane (7%), acetone (2%), unknown (13%).
With the rapid development of chemical substances, we look forward to future research findings about 311-86-4.
Reference:
Patent; MEXICHEM FLUOR S.A. DE C.V.; MURRAY, James Henry; SHARRATT, Andrew Paul; (32 pag.)WO2018/197897; (2018); A1;,
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