With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.37585-25-4, name is (2-Amino-5-chlorophenyl)methanol, molecular formula is C7H8ClNO, molecular weight is 157.6, as common compound, the synthetic route is as follows.Application In Synthesis of (2-Amino-5-chlorophenyl)methanol
To 40 ml of DMS0 in the reactor, PdCl2 (dppf), organic ligand L1, potassium carbonate and an auxiliary agent, And 12 mmol of the compound of formula (I) and 18 mmol of the compound of formula (II) in the above reaction scheme, with nitrogen being inert to formAtmosphere, sealed reaction at 110 C for 5 hours, the reaction is completed by natural cooling, vacuum concentration, the use of petroleum ether and ethyl acetate(1: 2 by volume) as the eluent to give the compound of the above formula (III) in a yield of96.7%;[0053] wherein the molar amount of the PdCl2 (dppf) is 1.2% by mol of the compound of the formula (I), and the ligand LlIs used in an amount of 3% by mol based on the molar amount of the compound of formula (I), the molar amount of said potassium carbonate being a molar amount of the compound of formula (I)35% and the molar amount of said auxiliary PhSiH3 is 1.5% by mol based on the compound of formula (I).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,37585-25-4, (2-Amino-5-chlorophenyl)methanol, and friends who are interested can also refer to it.
Reference:
Patent; Wang, Wenming; (10 pag.)CN104557737; (2016); B;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts