Electric Literature of 756520-66-8 ,Some common heterocyclic compound, 756520-66-8, molecular formula is C8H7Cl2FO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a stirred solution of triphenyl phosphine (8. 2 G, 0. 03 mol) and DEAD (13. 65 mL of a 40% solution in toluene) in THF (200 mL) at 0 C was added a solution of 1- (2, 6-DICHLORO-3-FLUORO-PHENYL)- ethanol (4. 55 G, 0. 021 mol) and 3-hydroxy-nitropyridine (3. 35 G, 0. 023 mol) in THF (200 mL). The resulting bright orange solution was stirred under a nitrogen atmosphere at ambient temperature for 4 hours at which point all starting materials had been consumed. The solvent was removed, and the crude material was dry loaded onto silica gel, and eluted with ethyl acetate-hexanes (20 : 80) to yield 3- (2, 6-DICHLORO-3-FLUORO-BENZYLOXY)-2-NITRO-PYRIDINE (6. 21 G, 0. 021 mol, 98%) as a pink SOLID. 1H NMR (CDCl3, 300 MHz) 1. 8-1. 85 (d, 3H), 6. 0-6. 15 (q, 1H), 7. 0-7. 1 (t, 1H), 7. 2-7. 21 (d, 1H), 7. 25-7. 5 (m, 2H), 8. 0-8. 05 (d, 1 H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 756520-66-8, 1-(2,6-Dichloro-3-fluorophenyl)ethanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SUGEN, INC.; WO2004/76412; (2004); A2;,
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