With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.111-90-0, name is Diethylene Glycol Monoethyl Ether, molecular formula is C6H14O3, molecular weight is 134.1736, as common compound, the synthetic route is as follows.COA of Formula: C6H14O3
A. Preparation of 1-Allyloxy-2-(2′-ethoxyethoxy) ethanol (4A) All procedures were the same as for preparation of 1A except that diethylene glycol monoethyl ether (39.0 mL, 0.288 mmoles) was used. After filtering the sodium bromide precipitate and concentrating the filtrate, the product was chromatographed on silica gel (eluents: toluene, 15% ethyl acetate in toluene, then 50% ethyl acetate in toluene) and then purified by fractional distillation to produce an 80% yield of colorless liquid, b.p. 78-79 C. at 0.2 torr. 1 H NMR:delta1.02 (t, J=7.0 Hz, –O–C–CH3); 3.28 (q, J=6.5 Hz, –O–CH2 C); 3.30 [m, W1/2 =4 Hz (CH2 CH2 O)2 ]; 3.77 (d, J=5.0 Hz, CH2 allyloxy); 4.69-5.22 (m, CH2 vinyl); 5.29-6.02 (m, CH vinyl).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,111-90-0, Diethylene Glycol Monoethyl Ether, and friends who are interested can also refer to it.
Reference:
Patent; Northeastern University; US4778909; (1988); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts