Adding a certain compound to certain chemical reactions, such as: 552331-15-4, 1-(5-Bromo-2-fluorophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 552331-15-4, blongs to alcohols-buliding-blocks compound. COA of Formula: C8H8BrFO
To a stirred solution of 1 -(5 -bromo-2-fluorophenyl)ethanol 30-1 (1.2 g, 5.48 mmol) in DCM (15 ml) was added tribromophosphine (0.26 mL, 2.74 mmol). The reaction mixture was stirred at 0C for lh, and then diluted with DCM (50 mL). Then saturated NaHCO3 solution was added dropwise to the mixture, and the layers were separated. The organic layer was washed with saturated NaHCO3 solution (3OmL), brine (30 mL), and then dried over Na2SO4, and concentrated to give the crude product 30-2, which was used in the next step without purification.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,552331-15-4, its application will become more common.
Reference:
Patent; MERCK SHARP & DOHME CORP.; HAGMANN, William K.; NARGUND, Ravi P.; BLIZZARD, Timothy A.; JOSIEN, Hubert; BIJU, Purakkattle; PLUMMER, Christopher W.; DANG, Qun; LI, Bing; LIN, Linus S.; CUI, Mingxiang; HU, Bin; HAO, Jinlai; CHEN, Zhengxia; WO2014/19186; (2014); A1;,
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