In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 530-91-6, name is 1,2,3,4-Tetrahydronaphthalen-2-ol, the common compound, a new synthetic route is introduced below. SDS of cas: 530-91-6
A solution of alcohol 13 (262 mg, 1.77 mmol, 1 eq.), nosyl chloride (781.5 mg, 3.53 mmol,2.0 eq.), DMAP (73.2 mg, 0.60 mmol, 0.34 eq.) and Et3N (0.74 mL,540.2 mg, 5.34 mmol, 3.0 eq.) in CH2Cl2 (6 mL) wasstirred vigorously for 16 h at rt. 2M NaOH (6 mL) was added and the reactionmixture was extracted with CH2Cl2 (3 x 5 mL). The organiclayer was washed with 2M NaOH (7 mL), dried (Na2SO4),filtered and concentrated in vacuo. The crude product was purified by fc (d = 3cm, l = 13 cm, v = 25 mL, cyclohexane:EtOAc 8:2, Rf = 0.55) to obtain a colorlessoil, yield 380.0 mg (64 %). C16H15NO5S (333.4g/mol). 1H NMR (400 MHz, CDCl3): delta (ppm) = 2.03 – 2.15(m, 2H, 3-CH2), 2.77 – 2.85 (m, 1H, 1-CH2), 2.92 – 3.02(m, 2H, 4-CH2), 3.08 (dd, J = 16.8/4.9 Hz, 1H, 1-CH2),5.10 – 5.15 (m, 1H, 2-CH), 6.95 (dd, J = 7.3/1.5 Hz, 1H,tetraline), 7.05 – 7.16 (m, 3H, tetraline), 8.08 – 8.14 (m, 2H, nos), 8.35 -8.40 (m, 2H, nos).
The synthetic route of 530-91-6 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Bechthold, Elena; Gawaskar, Sandeep; Robaa, Dina; Schepmann, Dirk; Schreiber, Julian A.; Seebohm, Guiscard; Sippl, Wolfgang; Temme, Louisa; Wuensch, Bernhard; European Journal of Medicinal Chemistry; vol. 190; (2020);,
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