Reference of 163119-16-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 163119-16-2, name is 2,6-Di-tert-butyl-4-methylcyclohexanol, molecular formula is C15H30O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Cyanoacetic acid 46.8 g (0.55 mol), toluene 320ml was added to 2,6-di-tert-butyl-4-methylcyclohexanol 113 g (0.5 mol), subjected to stirring at room temperature, whereas, pyridine 43 .5g the (0.55mol) was dropped. Then, dropping acetic anhydride 112.3g (1.1mol), it was 15 hours heated and stirred at 60C. After completion of the reaction, the reaction solution, sodium hydrogen carbonate of 95g, poured slowly with stirring in an aqueous solution consisting of water 750ml. Then, extracted with ethyl acetate of 250ml, after concentrating the ethyl acetate layer, the methanol 400ml added to the residue, after being heated and dissolved at 60C , to precipitate a crystal was cooled to 0C It was. The crystals were filtered, washed with water, by performing the methanol wash, to afford intermediate 4 135g (92% yield).
According to the analysis of related databases, 163119-16-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; FUJIFILM CORPORATION; SASAKI, DAISUKE; (63 pag.)JP5908824; (2016); B2;,
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