Reference of 33036-62-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 33036-62-3, name is 4-Bromo-1-butanol, molecular formula is C4H9BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Crude product 4-bromo-butanol was dissolved in DCM (500 ml) and dried over Na2SO4 and p-TosOH (500 mg) was added. Dihydropyran (1181 ml) was added dropwise at 0 C. and during the addition the temperature was kept under 8 C. The reaction was allowed to reach RT overnight, washed with saturated NaHCO3 solution (2¡Á300 ml) and brine (9.3 I). The aqueous layers were washed with TBME (300 ml) and the combined organic layers were dried over anhydrous K2CO3. The mixture was filtered off and the solvent was removed on the rotary evaporator. This yielded 593 g (yield=25% over 2 steps). The obtained 4-bromo-butanol-THP ether was filtrated twice over SiO2 (DCM with 1% MeOH). Finally, the compound was purified by column chromatography (20 I SiO2, DCM with 1% MeOH). This yielded 220.6 g of 2-(4-Bromo-butoxy)-tetrahydro-pyran (yield=9.3% over 2 steps) as a TLC-pure light yellow oil.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 33036-62-3, 4-Bromo-1-butanol.
Reference:
Patent; Solvay Pharmaceuticals GmbH; US2005/192263; (2005); A1;,
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