Adding a certain compound to certain chemical reactions, such as: 3376-59-8, 2,3-Dihydroxypropyl benzoate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 3376-59-8, blongs to alcohols-buliding-blocks compound. SDS of cas: 3376-59-8
To a solution of 35.5 g (181 mmol) of (-)-1-benzoyl glycerol (G) in 250 ml of dry pyridine at 0 C. is added 83 g (433 mmol) of p-toluenesulfonyl chloride. The mixture is stirred at 0 C. for 15 minutes and then stored in a refrigerator for 144 hours. After cooling the reaction mixture to 0 C., 10 ml of water are added, the mixture is stirred for 10 minutes, and then poured into excess water. The aqueous solution is separated from the gummy product, and extracted with chloroform. The gummy residue is dissolved in chloroform and the combined chloroform solution is washed sequentially with 3 N hydrochloric acid, water, 5% sodium bicarbonate solution, and water. The chloroform solution is dried over Na2 SO4 and concentrated under reduced pressure to obtain a solid which, upon recrystallization from absolute ethanol, gives 65.5 g (130 mmol, 72%) of (-)-1-benzoyl-2,3-di-p-toluenesulfonyl glycerol (see Formula (H) in Scheme 2), m.p. 105-106 C. [alpha]D2 -22.7 (c, 5.92, CHCl3). 1 H NMR (CDCl3) delta8-7 (m, 13H); 4.9 (m, 1H); 4.45 (d, 2H, J=6 Hz); 4.35 (d, 2H, J=5 Hz); 2.42 (s, 3H); 2.38 (s, 3H). 13 C NMR (CDCl3) 165.162, 145.136, 133.108, 132.466, 131.649, 129.430, 128.671, 128.087, 127.678, 75.306, 66.899, 61.994, 21.591 ppm.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3376-59-8, its application will become more common.
Reference:
Patent; Stille; John K.; US4393240; (1983); A;,
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