Month: February 2021

Related Products of 329218-12-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 329218-12-4, name is 3-Bromo-4-chlorobenzyl Alcohol. This compound has unique chemical properties. The synthetic route is as follows.

c. 3-Bromo-4-chloro-benzaldehyde To a solution of 3-bromo-4-chlorobenzyl alcohol (2.73 g, 12.34 mmol) in dichloromethane (75 mL) was added, at room temperature, pyridinium chlorochromate (2.66 g, 12.34 mmol). The reaction mixture was stirred at room temperature for 1 hr then filtered over celite. The solvent was removed under reduced pressure and the residue chromatographed on silica gel (10% ethyl acetate in hexane) to afford 2.52 g of 3-bromo-4-chloro-benzaldehyde (93% yield). 1H NMR (300 MHz; CDCl3) 1H NMR (300 MHz; CDCl3) 7.65 (d, J=8.1 Hz, 1H); 7.78 (dd, J1=8.4 Hz, J2=2.1 Hz, 1H); 8.12 (d, J=2.1 Hz, 1H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 329218-12-4, 3-Bromo-4-chlorobenzyl Alcohol.

Reference:
Patent; Maxia Pharmaceuticals, Inc.; US6515003; (2003); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 52059-53-7, name is 2-(3-Fluorophenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. category: alcohols-buliding-blocks

Example 149E (20 mg, 0.06 mmol) and 2-(3-fiuorophenyl)ethanol (9.3 mg, 0.066 mmol) were dissolved in 1 mL tetrahydrofuran. To this, PS-triphenylphosphine (58 mg, 0.18 mmol, 3.1 mmol/g) was added followed by di-tert-buty azodicarboxylate (20.9 mg, 0.09 mmol). The mixture was stirred at room temperature overnight. The resulting mixture was filtered, concentrated and purified by flash chromatography (0-50% ethyl acetate in hexane). To the material thus obtained was added 0.5 mL 4 MEtaC1 in dioxane. The reaction was stirred at 50 0C until completion. The mixture was concentrated to give the title compound as the hydrochloride salt. 1H NMR (500 MHz, DMSO-J6) delta ppm 9.44 (br, IH), 9.07 (br, 2H), 7.36 (dd, J = 14.4, 7.9 Hz, IH), 7.18 (t, J = 8.0 Hz, 2H), 7.05 (td, J = 8.8, 2.4 Hz, IH), 6.87 (d, J = 8.6 Hz, IH), 6.70 – 6.54 (m, 2H), 4.26 – 4.08 (m, 2H), 3.59 – 3.47 (m, IH), 3.30 (m, 4H), 3.11 – 2.85 (m, 4H), 2.60 (dd, J = 13.4, 7.0 Hz, IH), 1.97 (d, J = 13.5 Hz, IH).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 52059-53-7, 2-(3-Fluorophenyl)ethanol.

Reference:
Patent; ABBOTT LABORATORIES; ABBOTT GMBH &; CO. KG; WANG, Ying; BREWER, Jason, T.; AKRITOPOULOU-ZANZE, Irini; DJURIC, Stevan, W.; POHLKI, Frauke; BRAJE, Wilfried; RELO, Ana-Lucia; WO2010/124042; (2010); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 5333-42-6, 2-octyldodecan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2-octyldodecan-1-ol, blongs to alcohols-buliding-blocks compound. Recommanded Product: 2-octyldodecan-1-ol

Take 0.1g (452g/mol, 0.22mmol)Diisobutyl 3,9-nonanedicarboxylate in a round bottom flask, adding 1.63g(298 g/mol, 5.5 mmol) of 2-octyldodecanol was heated to 100 C,Add 0.01 g (10 wt%) of dihydroxybutyl tin chloride to the reaction flask,The temperature was raised to 170 C, and the reaction was heated for 3 h, and the plate was tracked during the reaction.After the reaction, the reaction was cooled to room temperature and the temperature was raised to 180 C.Vacuum distillation,Distilling off excess 2-octyldodecanol which acts as both a solvent for the reaction and a reactantDry in vacuum. The resulting product was cooled to room temperature and dissolved in petroleum ether.The wet method was purified by silica gel column to obtain a yellow dye. The conversion was calculated to be 90%.

The synthetic route of 5333-42-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shenzhen Guohua Optoelectric Technology Co., Ltd.; Shenzhen Guohua Optoelectric Institute; Zhou Guofu; Deng Yong; Li Shi; Ye Dechao; (8 pag.)CN109627802; (2019); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 23147-58-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 23147-58-2, name is Glycerol aldehyde dimer. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of (4-chloro-3-fluorophenyl)methanamine (266 mg, 1.67 mmol, Alfa) in a methanol buffer (3.6 weight % sodium acetate trihydrate and 2.4 weight % acetic acid in methanol, 15mL) was added l,4-dioxane-2,5-diol (100 mg, 0.833 mmol, Aldrich) in one portion followed by sodium cyanoborohydride (105 mg, 1.67 mmol) and trifluoroacetic acid (0.1 mL). After stirring at ambient temperature for 10 minutes, the reaction mixture was concentrated under reduced pressure to less than 5 mL and was filtered through a glass microfiber frit. Then the filtrate was purified by preparative HPLC [YMC TriArt CI 8 Hybrid 5 mupiiota column, 50 x 100 mm, flow rate 140 mL/minute, 5-100% gradient of acetonitrile in buffer (0.025 M aqueous ammonium bicarbonate, adjusted to pH 10 with ammonium hydroxide)] to give the title compound (0.18 g, 0.88 mmol, 53.0 % yield). MS (ESI+) mJz 204 (M+H)+.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 23147-58-2, Glycerol aldehyde dimer.

Reference:
Patent; CALICO LIFE SCIENCES LLC; ABBVIE INC.; MARTIN, Kathleen, Ann; SIDRAUSKI, Carmela; PLIUSHCHEV, Marina, A.; FROST, Jennifer, M.; TONG, Yunsong; XU, Xiangdong; SHI, Lei; ZHANG, Qingwei, I.; XIONG, Zhaoming; SWEIS, Ramzi, Farah; DART, Michael, J.; MURAUSKI, Kathleen; (288 pag.)WO2019/90074; (2019); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 431-38-9, 3-Amino-1,1,1-trifluoropropan-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

Preparation 10: 4-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3,3,3-trifluoro-2-hydroxypropyl)-1-naphthamide To a solution of 4-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-1-naphthoic acid (Preparation 7, 1 g, 2.1 mmol) in DMF (25 mL) was added HATU (970 mg, 2.5 mmol) and triethylamine (1.0 mL, 7.0 mmol).The reaction was stirred at room temperature for 15 minutes then treated with 3-amino-1,1,1-trifluoro-2-propanol (275 mg, 2.1 mmol). The reaction was stirred at room temperature for 18 hours. Next, the reaction was diluted with 0.1NNaOH and extracted with EtOAc (2¡Á150 mL). The combined organic phase was dried (Na2SO4) and concentrated under vacuum. The crude material was chromatographed (80 g Redi-Sep column) eluting from 100% heptane to 40:60 EtOAc:heptane to afford the intermediate (1.06 g, 85%) as a solid. 1HNMR (CDCl3) delta ppm: 8.81 (1H), 8.28 (1H), 7.71-7.57 (5H), 7.49 (1H), 6.55 (1H) 4.32-4.25 (3H), 4.08-3.91 (1H), 3.85 (1H), 3.79-3.74 (1H); m/z (Cl) 583 [M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,431-38-9, 3-Amino-1,1,1-trifluoropropan-2-ol, and friends who are interested can also refer to it.

Reference:
Patent; PFIZER INC.; US2012/77765; (2012); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 2568-33-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2568-33-4, name is 3-Methylbutane-1,3-diol, molecular formula is C5H12O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Into a 1 L three-necked flask equipped with a stirrer, a dry air inlet tube, a thermometer, a distillation column (inner diameter 25 mm ¡Á height 300 mm, packing tower packed with 6 mm McMahon packing) and a distillation head,100 g of 3-methyl-3-hydroxy-1-butyl alcohol, 240 g of methyl methacrylate,0.24 g of 2,2,6,6-tetramethyl-4-hydroxypiperidine-N-oxide as a polymerization inhibitor was charged,While stirring while blowing a small amount of air,The inside of the system was heated to 100 to 110 C. 8 g of methyl methacrylate was withdrawn from the top portion of the distillation column. After cooling the inside of the system to 40 C., 0.55 g of magnesium diethoxide was charged as a catalyst, and a small amountWhile blowing air while stirring,The inside of the system was heated to 100 to 130 C. Methanol produced as the reaction proceeded was gradually withdrawn from the top of the distillation column by azeotropic distillation with methyl methacrylate to allow the reaction to proceed.The conversion of 3-methyl-3-hydroxy-1-butyl alcohol 7 hours after the start of the reaction was 78.3%. The reaction was further continued, and after 9 hours from the start of the reactionThe conversion of 3-methyl-3-hydroxy-1-butyl alcohol was 94.0%The yield of 3-methyl-3-hydroxy-1-butyl methacrylate based on 3-methyl-3-hydroxy-89.3%,The diester yield based on 3-methyl-3-hydroxy-1-butyl alcohol was 1.7%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 2568-33-4, 3-Methylbutane-1,3-diol.

Reference:
Patent; Mitsubishi Gas Chemical Company; Kushida, Eriko; Takemoto, Makiko; (16 pag.)JP2018/135285; (2018); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 186020-66-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 186020-66-6, name is tert-Butyl 12-Hydroxy-4,7,10-trioxadodecanoate. This compound has unique chemical properties. The synthetic route is as follows.

Step 2: 3-{2-[2-(2-Tosylsulfonyloxy-ethoxy)-ethoxy]-ethoxy}-propionic acid tert-butyl ester Tosyl chloride (22.3 g, 117 mmol) was added in portions to a stirring solution of 3-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-propionic acid tert-butyl ester (16.3 g, 58.6 mmol) and pyridine 60 mL in (240 mL) and the mixture was stirred overnight. The reaction was quenched with water (300 mL) and the organic layer was separated. The aqueous layer was extracted with CH2Cl2 (2*100 mL). The combined organic layer was washed with HCl (1N, 100 mL), water (100 mL), and dried over Na2SO4 and the solvent was removed in vacuo to give an oil which corresponds to the title compound that would be used as is for the next step. (M+1)=433.

According to the analysis of related databases, 186020-66-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BRADSHAW, Curt W.; Sakamuri, Sukumar; Fu, Yanwen; Oates, Bryan; Desharnais, Joel; Tumelty, David; US2009/98130; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 1875-89-4, 2-(m-Tolyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2-(m-Tolyl)ethanol, blongs to alcohols-buliding-blocks compound. Safety of 2-(m-Tolyl)ethanol

Example 8-2- [2- (3-methylphenyl) ethoxy]-2′, 3′, 5-TRI-O-(TERT- butyldimethylsilyl)-adenosine [54] To a dry 250-mL, 3-neck roundbottom flask was added 2-chloro- 2′, 3′, 5-TRI-O-(TERT-BUTYLDIMETHYLSILYL) adenosine (5 g, 7.8 mmol, Example 1) and 2- (3-methylphenyl) ethanol (15 mL). The mixture was flushed with nitrogen for 5-10 minutes, then heated to 50 ¡ãC. To this mixture was added sodium hydride (1.56 g, 39 mmol, as a 60percent dispersion in mineral oil) at such a rate as to avoid excessive gas evolution. The reaction was maintained at 50 ¡ãC until the predominant component was the product by HPLC (partially deprotected products were also seen). The reaction was then cooled to room temperature, carefully quenched with water (40 mL), and extracted with ethyl acetate (3 x 100 mL). The combined organic extracts were washed with brine (120 mL), dried (MGS04), filtered, and concentrated under reduced pressure to afford a brown oil. This material was purified by passing through a plug of silica gel, eluting with CH2CL2, 5percent methanol in CHSCIS, and 10percent methanol in CH2CL2. Those fractions containing products were combined and evaporated to dryness, to afford a mixture of starting material and monosilyl-protected and disilyl-protected alkylated products in a ratio of 2: 5: 12.This mixture was used without further purification in the next step

The synthetic route of 1875-89-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; KING PHARMACEUTICALS RESEARCH & DEVELOPMENT, INC.; WO2005/33121; (2005); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 15484-46-5, name is Methyl 2-(hydroxymethyl)acrylate. A new synthetic method of this compound is introduced below., Recommanded Product: 15484-46-5

General procedure: Into a round bottom flask charged with a magnetic stirbar was added 1 equiv. MBH adduct, followed by 3 equiv. 33wt % HBr (in HOAc). The solution was vigorously stirred until judged complete by TLC, then was poured into a 1 : 1 (volumetric) mixture of deionized water and CH2Cl2. The organic layer was separated, then the residual product was extracted from the aqueous layer with an additional portion of CH2Cl2. The combined organic layers were washed with deionized water then brine, then were dried with Na2SO4, filtered, concentrated, and purified via column chromatography.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 15484-46-5, Methyl 2-(hydroxymethyl)acrylate.

Reference:
Article; Nicponski, Daniel R.; Tetrahedron Letters; vol. 55; 13; (2014); p. 2075 – 2077;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 552331-15-4, Adding some certain compound to certain chemical reactions, such as: 552331-15-4, name is 1-(5-Bromo-2-fluorophenyl)ethanol,molecular formula is C8H8BrFO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 552331-15-4.

Preparation of 5-bromo-3-methyl-1/-/-indazole 104; Scheme 2 EPO To a solution of 5-bromo-2-fluorobenzaldehydbeta 101 (100 g, 0.492 mol.) in ether (500 ml_), cooled in an ice bath, was added a 3 M solution of methyl magnesium bromide in ether (i.e., diethyl ether) (173 mL, 0.516 mol.) in a dropwise manner. The reaction mixture was stirred for 30 minutes in the ice bath. The reaction mixture was allowed to warm to room temperature and was stirred for 15 minutes. The reaction mixture was cooled in an ice bath and the reaction was quenched by addition of water in a dropwise manner. The reaction mixture was acidified with dilute hydrochloric acid. The organic layer was separated. The aqueous layer was extracted with ether for two times. The combined organic layer was dried over magnesium sulfate and evaporated under reduced pressure to afford 1-(5-bromo-2-fluoro-phenyl)- ethanol 102 (106 g, 0.484 mol.) which was used in the next step without further purification. To a solution of 1 -(5-bromo-2-f luoro-phenyl)-ethanol 102 (105 g, 0.479 mol.) in dioxane (2 L) was added manganese dioxide (203 g, 2.35 mol.). The reaction mixture was heated under reflux for 5 hours. The reaction mixture was allowed to cool to room temperature. The reaction mixture was filtered through Celite (i.e., diatomaceous earth) and the solid was washed with ether (1 L). The combined filtrate was evaporated under reduced pressure to afford the 1-(5-bromo-2-fluoro-phenyl)-ethanone 103 (95.7 g, 0.441 mol.) which was used in the next step without further purification.

According to the analysis of related databases, 552331-15-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SCHERING CORPORATION; WO2006/81230; (2006); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts