Month: January 2021

Reference of 1450754-41-2 ,Some common heterocyclic compound, 1450754-41-2, molecular formula is C7H10N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenyl)picolinic acid, an intermediate with a monocarboxylic acid(0.063g, 0.145mmol)Dissolved in 3mL anhydrous tetrahydrofuran solution,Add EDC¡¤HCl (0.04 g, 0.218 mmol),HOBT (0.024 g, 0.174 mmol) was stirred well at 0 C, then DIPEA (0.094 g, .725 mmol) was added dropwise and stirred.1h,Add inPhotoaffinity group dipyridiniumAlkynyl chainConnector(0.02g, 0.145mmol),Stir at room temperature for 24 h,After the reaction is completed, the solvent is removed under reduced pressure, and an appropriate amount of ethyl acetate is added thereto, followed by washing with water and washing with saturated sodium hydrogen carbonate, and then sat.Washed with brine, combined with EtOAc (EtOAc m.The target compound was obtained, and weighed 0.03 g, yield 41.66%. Obtaining a general formula based on the VEGFR-2 inhibitor B14 photoaffinity probe

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1450754-41-2, 2-(3-But-3-ynyl-3H-diazirin-3-yl)-ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Xi’an Jiaotong University; Zhang Jie; Lu Wen; Wang Sicen; Pan Xiaoyan; He Langchong; Sun Ying; Wang Jin; Song Jie; (10 pag.)CN109503553; (2019); A;,
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Related Products of 30379-58-9 ,Some common heterocyclic compound, 30379-58-9, molecular formula is C9H10O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of lithium 3-(cyclopropylmethoxy)-4-(N-(2-(4-methylpiperazin- l-yl)ethyl)methylsulfonamido)benzoate (theoretical 0.869 mmol) and EDC (349 mg, 1.821 mmol) in dry DCM (3 ml), benzyl 2-hydroxyacetate (151 mg, 0.910 mmol) and DMAP (1 1 1 mg, 0.910 mmol) were added at RT. The final mixture was stirred for 2 days, then the solvent was evaporated, the residue was portioned between water and EtOAc, the organic layer was washed with NaHC03 sat. sol. and brine, dried over Na2S04 and evaporated. The crude was purified by flash chromatography on silica gel (eluent: DCM/MeOH/32%NH4OH 95/5/0.5) to give 2-(benzyloxy)-2- oxoethyl 3-(cyclopropylmethoxy)-4-(N-(2-(4-methylpiperazin-l-yl)ethyl)- methylsulfonamido)benzoate as a colorless oil (370 mg, 0.661 mmol, 76% yield over 2 steps, MS/ESI+ 560.1 [MH] +).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 30379-58-9, Benzyl 2-hydroxyacetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; CHIESI FARMACEUTICI S.P.A.; ARMANI, Elisabetta; AMARI, Gabriele; CAPALDI, Carmelida; ESPOSITO, Oriana; PERETTO, Ilaria; WO2013/45280; (2013); A1;,
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Adding a certain compound to certain chemical reactions, such as: 4845-50-5, 1,4-Dioxane-2,3-diol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 1,4-Dioxane-2,3-diol, blongs to alcohols-buliding-blocks compound. Quality Control of 1,4-Dioxane-2,3-diol

To a solution of the corresponding compound 39G (0.9 mmol) in ethanol/water (30 mL/4 mL) was added l,4-dioxane-2,3-diol (130 mg, 1.08 mmol) and the resulting suspension was stirred at 30C overnight. The solvent was removed in vacuo and the residue was partitioned between water and EtOAc. The organic layer was separated and washed with water and brine, dried over Na2S04 and concentrated, and then purified by a standard method to give title product 39H.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,4845-50-5, 1,4-Dioxane-2,3-diol, and friends who are interested can also refer to it.

Reference:
Patent; AGIOS PHARMACEUTICALS, INC.; POPOVICI-MULLER, Janeta; ZAHLER, Robert; YE, Zhixiong; WO2014/139144; (2014); A1;,
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Application of 623-04-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 623-04-1, name is (4-Aminophenyl)methanol, molecular formula is C7H9NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of p-amino-benzylalcohol (1 g, 8.12 mmol, 1 eq) in 80 mL of anhydrous THF were added DIEA (1.4 mL, 8.12 mmol, 1 eq) and BoC2O (1.9 mL, 8.12 mmol, 1 eq). The mixture was heated to reflux overnight, then cooled down and evaporated under vacuum. The residue was dissolved in EtOAc. The organic layer was washed with a 0.1 N HCl solution, dried over MgSO4, filtered and evaporated under vacuum. The crude product was purified by column chromatography on silica gel (Hex-EtOAc, 1:1, v/v) to give 1.85 g of product (quantitative yield): 1H NMR delta 0.1.49 (9H, s), 2.17 (IH, s), 4.53 (2H5 s), 6.83 (IH, s), 7.19 (2H, d, J = 8.5 Hz), 7.28 (2H, d, J = 8.2 Hz); 13 C NMR delta 28.28, 64.54, 80.37, 118.49, 127.59, 135.31, 137.46, 152.72.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 623-04-1, (4-Aminophenyl)methanol.

Reference:
Patent; ENZON PHARMACEUTICALS, INC.; WO2008/34124; (2008); A2;,
Alcohol – Wikipedia,
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Synthetic Route of 504-63-2 ,Some common heterocyclic compound, 504-63-2, molecular formula is C3H8O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 3 2-(2-Bromophenyl)-[1,3]dioxane (5a). ortho-Bromobenzaldehyde (4a) (8 g, 43.24 mmol) was stirred with 1,3 propanediol (4.7 ml, 64.86 mmol) and p-toluenesulfonic acid monohydrate (164 mg, 0.86 mmol) in benzene (150 ml) in a flask equipped with a Dean-Stark trap and a condenser. The mixture was heated at reflux for 12 hrs, cooled, and extracted with 2 M NaOH (100 ml), and brine (100 ml*3). The solution was dried over MgSO4, and the solvent evaporated to the title compound in quantitative yield.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 504-63-2, 1,3-Propanediol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PURDUE RESEARCH FOUNDATION; US2009/30025; (2009); A1;,
Alcohol – Wikipedia,
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Reference of 39590-81-3, Adding some certain compound to certain chemical reactions, such as: 39590-81-3, name is 1,1-Bis(Hydroxymethyl)cyclopropane,molecular formula is C5H10O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39590-81-3.

General procedure: The diol (48 mmol, 1 eq) wasdissolved into DMF (120 mL) under argon. At 0C NaH (1.1 eq, 60% in mineral oil) was added inone portion and the mixture was stirred at 0C during 45 min. BnBr (0.97 eq) was added dropwise,the mixture was allowed to warm at room temperature and stirred overnight. The reaction wasquenched with saturated NH4Cl solution (20 mL) and then diluted with water. The crude mixturewas extracted with Et2O and the organic layer was washed with brine, dried over anhydrous MgSO4,filtered and concentrated in vacuo. Benzylated compound was then purified by flashchromatography on silica gel.

According to the analysis of related databases, 39590-81-3, the application of this compound in the production field has become more and more popular.

Reference:
Article; Chalopin, Thibaut; Jebali, Khaoula; Gaulon-Nourry, Catherine; Denes, Fabrice; Lebreton, Jacques; Mathe-Allainmat, Monique; Tetrahedron; vol. 72; 2; (2016); p. 318 – 327;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 16545-68-9, name is Cyclopropanol. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C3H6O

Methyl 2-([1-[(2-chlorophenyl)methyl]-5-(4-cyclopropoxythien-2-yl)-1H-pyrazol-3-yl]methoxy)-2-methylpropanoate To a solution of the product from the previous step (350 mg, 0.72 mmol, 1.00 equiv) in dioxane (10 mL) was added stepwise Cs2CO3 (473 mg, 1.45 mmol, 2.00 equiv), 2nd Generation XantPhos precatalyst (322 mg, 0.36 mmol, 0.50 equiv), and cyclopropanol (168 mg, 2.89 mmol, 4.00 equiv). The final reaction mixture was irradiated with microwave radiation for 1 h at 85 C. The resulting solution was diluted with 100 mL of EtOAc. The resulting mixture was washed with 2¡Á100 mL of brine. The mixture was dried over anhydrous Na2SO4 and concentrated under vacuum. The residue was applied onto a silica gel column with EtOAc/petroleum ether (1:2). This resulted in the title compound as a yellow oil (150 mg, 45%).

With the rapid development of chemical substances, we look forward to future research findings about 16545-68-9.

Reference:
Patent; Vettore, LLC; PARNELL, Kenneth Mark; MCCALL, John; ROMERO, Donna; (172 pag.)US2018/162822; (2018); A1;,
Alcohol – Wikipedia,
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Synthetic Route of 41175-50-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 41175-50-2 as follows.

(Z)-/V-(11 -methyl-2, 3,6, 7-tetrahydro-1H,5H,12H-quinolizino[1,9-bc]phenoxazin-12- ylidene)ethanaminium (LGW-01-99). Compound 26 (50 mg, 0.26 mmol) was dissolved in a solution of /-PrOH/H20 (9/1 , 1 mL) at 80 C for 30 min. A suspended solution of 7 (50 mg, 0.27 mmol) and HCIO4 (70%, 30 m) in 90% /-PrOH (2 mL) was added in 4 portions over 1 h. The resulting solution was stirred overnight. After which, the dark blue solution was evaporated under reduced pressure, and the residue was purified on a Biotage Isolera Flash System using SNAP Ultra cartridge with a mobile phase of CHCI3 and MeOH containing 0.5% formic acid (gradient, 2-15% of MeOH in CHC ). The fractions containing product were pooled and evaporated, affording LGW-01-99 (33 mg, 33%) as a dark blue solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,41175-50-2, its application will become more common.

Reference:
Patent; OREGON HEALTH & SCIENCE UNIVERSITY; OREGON STATE UNIVERSITY; GIBBS, Summer L.; BARTH, Connor W.; ALANI, Wathah G.; SHAH, Vidhiben; WANG, Lei; (167 pag.)WO2020/33435; (2020); A1;,
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Application of 4415-82-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4415-82-1, name is Cyclobutylmethanol. A new synthetic method of this compound is introduced below.

To a mixture of 1.05 g (26.25 mmol; 60% purity) of sodium hydride in 15 ml of DMF were added 1.33 g (15.44 mmol) of cyclobutylmethanol and the mixture was stirred at RT for 1 h. Subsequently, a mixture of 1.0 g (7.72 mmol) of 3-chloropyrazin-2-amine in 10 ml DMF was added thereto and the reaction mixture was heated to 100 C. After 20 h, water was added to the mixture, which was extracted repeatedly with ethyl acetate. The combined organic phases were washed with saturated sodium chloride solution, dried over sodium sulphate, filtered and concentrated by evaporation. The residue obtained was purified by means of silica gel chromatography (eluent: cyclohexane/ethyl acetate gradient). 1.25 g of the title compound were obtained (89% of theory; 98% purity). (1270) LC-MS (Method 2): Rt=0.80 min (1271) MS (ESpos): m/z=180 (M+H)+

At the same time, in my other blogs, there are other synthetic methods of this type of compound,4415-82-1, Cyclobutylmethanol, and friends who are interested can also refer to it.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; VAKALOPOULOS, Alexandros; FOLLMANN, Markus; HARTUNG, Ingo; BUCHGRABER, Philipp; JAUTELAT, Rolf; LINDNER, Niels; WUNDER, Frank; STASCH, Johannes-Peter; REDLICH, Gorden; Dietz, Lisa; LI, Volkhart Min-Jian; (85 pag.)US2016/176880; (2016); A1;,
Alcohol – Wikipedia,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 112-27-6, name is 2,2′-(Ethane-1,2-diylbis(oxy))diethanol, the common compound, a new synthetic route is introduced below. COA of Formula: C6H14O4

Briefly, p-toluenesulfonyl chloride (7.50 g, 40.0 mmol) was added to a solution of triethylene glycol (60.0 g, 40.0 mmol) in pyridine (6.5 mL) and dichloromethane (400 mL) and under nitrogen. After stirring for 18 hr at room temperature, the solvent was concentrated under reduced pressure. The residue was dissolved in ethyl acetate (200 mL) and washed with aq. NaCl solution (3*200 mL). The aq. extract was back extracted with ethyl acetate (2*100 mL), and the combined ethyl acetate phases were dried over MgSO4. After filtering and evaporating to dryness the product was purified on a silica column to yield a clear oil (9.30 g, 75%). 1H NMR (300 MHz, CDCl3, TMS): delta 7.82 (d, 3JHH=8.1 Hz, 2H), 7.36 (d, 3JHH=8.1 Hz, 2H), 7.19 (t, 3JHH=3.6 Hz, 2H), 3.59-3.78 (m, 10H), 2.47 (s, 3H). 13C NMR (75 MHz, CDCl3, TMS): delta 144.86, 132.93, 129.82, 127.96, 72.48, 70.77, 70.34, 69.13, 68.70, 61.74, 21.62. IR (NaCl): v=3421, 2886, 1594, 1358, 1169, 664 cm31 1.

The synthetic route of 112-27-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Holmes, Brian T.; Snow, Arthur W.; US2009/187037; (2009); A1;,
Alcohol – Wikipedia,
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