Month: January 2021

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 69605-90-9, name is [1,1′-Biphenyl]-3-ylmethanol, the common compound, a new synthetic route is introduced below. Formula: C13H12O

Step 3. Preparation of (3-phenylphenyl)methyl-2-pyridyl-carbonate and 3-phenylphenyl)methyl-2-oxopyridine 1-carboxylate Under nitrogen atmosphere, to a stirred mixture of 3-phenylphenyl methanol (0.3 g, 1.63 mmol) in dry CH2Cl2 (3 mL), Et3N (0.340 mL, 2.44 mmol) and di-2-pyridyl carbonate (0.387 g, 1.79 mmol) were added. The reaction mixture was left at rt for 15 h, diluted with CH2Cl2 and washed first with a saturated NH4Cl solution (3 mL) and subsequently with a saturated NaHCO3 solution (3*3 mL). The organic fraction was dried over Na2SO4, filtered and concentrated to dryness to afford a dark oil (0.487 g, 98%), as a mixture (ratio 1:3) of 3-phenylphenyl)methyl-2-pyridyl-carbonate and 3-phenylphenyl)methyl-2-oxopyridine 1-carboxylate.

The synthetic route of 69605-90-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino ?Carlo Bo?; Piomelli, Daniele; Bandiera, Tiziano; Mor, Marco; Tarzia, Giorgio; Bertozzi, Fabio; Ponzano, Stefano; (102 pag.)US9353075; (2016); B2;,
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Electric Literature of 112-27-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 112-27-6, name is 2,2′-(Ethane-1,2-diylbis(oxy))diethanol. This compound has unique chemical properties. The synthetic route is as follows.

Phosphorus tribromide (0.47 mL, 5 mmol) was added dropwise to triethylene glycol (5) (3.0 g,20.0 mmol) at -10 C. Then, the reaction was stirred at room temperature for 4 h. After the completionof the reaction, H2O was added, and the pH was adjusted to 7 using 5 M NaOH, extracted with CH2Cl2and dried over anhydrous Na2SO4. Removal of the solvent under vacuum, followed by flash columnchromatography (2% MeOH/CH2Cl2) afforded 11 as yellow oil (1.57 g, 7.36 mmol, 49%)3; 1H NMR(400 MHz, CDCl3) delta 3.83 (t, J = 6.2 Hz, 1H), 3.76 – 3.72 (m, 1H), 3.69 (s, 2H), 3.64 – 3.60 (m, 1H),3.49 (t, J = 6.2 Hz, 1H); 13C NMR (100 MHz, CDCl3) delta 72.6, 71.2, 70.6, 70.4, 61.8, 30.3. The 1H and 13C spectroscopic data are in good agreement with those previously reported.

According to the analysis of related databases, 112-27-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Thanaussavadate, Bongkotrat; Ngiwsara, Lukana; Lirdprapamongkol, Kriengsak; Svasti, Jisnuson; Chuawong, Pitak; Bioorganic and Medicinal Chemistry Letters; vol. 30; 1; (2020);,
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Related Products of 73978-41-3 ,Some common heterocyclic compound, 73978-41-3, molecular formula is C7H9ClN6O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Initially, the compound 6-bromomethyl-pteridine-2,4-diamine as shown inFormula XIIIH9N N N(XIII)was prepared by first suspending 2,4-diamino-6-(hydroxymethyl)pteridine hydrochloride(2.29 g, 10 mmol) in 100 ml glacial acetic acid, warming to reflux and then allowing tocool to ambient temperature. Hydrobromic acid and 30% AcOH solution (191 ml) wasthen added and the flask stoppered for 4 days. The reaction mixture was then poured into1200 ml dry diethyl ether with stirring. The product was allowed to settle and excesssolvent was removed by decantation. The product was collected, washed with additionalether, and dried for later use.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,73978-41-3, its application will become more common.

Reference:
Patent; SERENEX, INC.; WO2006/14706; (2006); A2;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 7287-81-2, name is 1-(m-Tolyl)ethanol. A new synthetic method of this compound is introduced below., Application In Synthesis of 1-(m-Tolyl)ethanol

General procedure: A 20 ml vial equipped with a magnetic stirring bar was charged with secondary alcohols (0.3 mmol, 1 equiv.), NaN3 (0.75 mmol, 2.5 equiv.), n-hexane (1.0 ml, 0.3 M) and TFA (5.4 mmol, 18 equiv.) or a mixture of TFA (3.6 mmol,12 equiv.) and MeSO3H (1.8 mmol, 6 equiv.). The vial was sealed and stirred under air at 40 C for 4 h. On completion, the reaction mixture was quenched by 2 M NaOH (5 m), extracted by ethyl acetate (5 ¡Á 2 m) and the combined organic phase was washed with brine and dried over Na2SO4. Then the mixture was concentrated and purified by flash chromatography on a short silica gel column.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 7287-81-2, 1-(m-Tolyl)ethanol.

Reference:
Article; Liu, Jianzhong; Qiu, Xu; Huang, Xiaoqiang; Luo, Xiao; Zhang, Cheng; Wei, Jialiang; Pan, Jun; Liang, Yujie; Zhu, Yuchao; Qin, Qixue; Song, Song; Jiao, Ning; Nature Chemistry; vol. 11; 1; (2019); p. 71 – 77;,
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Electric Literature of 39895-56-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 39895-56-2 as follows.

To a mixture of 4-pyrrolidin-1-ylbenzoic acid (2.0 g, 10.5 mmol), (4- aminomethylphenyl) methanol (4.3 g, 31.4 mmol), 1-hydroxybenzotriazole (1.7 g, 12.6 mmol), and DMAP (256 mg, 2.1 mmol) in pyridine (50 mL) was added EDC (3.0 g, 15.7 mmol), and the mixture was stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure, and an aqueous NaHCO3 solution (50 mL) was added. The mixture was extracted with 5% MeOH in CHC13 (150 mL x 2), and the organic layer was dried (MgS04) and evaporated under reduced pressure. The crude product was purified by MPLC on silica gel (3% MeOH in CHC13) to afford the titled compound (2.56 g, 79%) as a white solid. H NMR (DMSO-d6) 8 1.96 (m, 4H), 3.28 (m, 4H), 4.41-4. 47 (m, 4H), 5.10 (t, 1H, J= 5.7 Hz), 6.53 (m, 2H), 7.25 (apparent s, 4H), 7.75 (m, 2H), 8. 59 (br t, 1H, J=6.0 Hz)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,39895-56-2, its application will become more common.

Reference:
Patent; SK CHEMICALS, CO., LTD.; IN2GEN CO., LTD.; WO2003/87066; (2003); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6966-10-5, name is (3,4-Dimethylphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: (3,4-Dimethylphenyl)methanol

The 0.91 g (0.0067 muM) of 3, 4 – dimethyl benzoic alcohol and GO – Ti compound 0.35 g dispersed in 10 ml methanol in the in the oil bath and heating to 60 C, 2.3 g (0.02 muM) of 30 wt % aqueous hydrogen peroxide solution in methanol is slowly added. After adding after keeping the temperature reaction 5 h, HPLC detection by 3, 4 – dimethylphenyl methanol conversion rate of 90.1%, 3, 4 – dimethyl benzaldehyde selectivity of 98.5%. The concentrated filtrate after filtering to remove the catalyst, after separation by silica gel column chromatography to obtain 3, 4 – dimethyl benzaldehyde 0.79 g, yield 87.8%.

With the rapid development of chemical substances, we look forward to future research findings about 6966-10-5.

Reference:
Patent; Shenyang Pharmaceutical University; Wang Qinghe; Cheng Maosheng; Ma Wenxi; Tong Qiaolin; Wang Shicheng; (8 pag.)CN108395369; (2018); A;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 14002-80-3, name is Methyl 3-hydroxy-2,2-dimethylpropanoate. This compound has unique chemical properties. The synthetic route is as follows. Formula: C6H12O3

Preparation of methyl 3-(tert-butyldimethylsilyloxy)-2,2-dimethyl- propanoate: Methyl 3-hydroxy-2,2-dimethylpropanoate (1.000 g, 7.567 mmol), TBDMS-Cl (1.140 g, 7.567 mmol) and imidazole (0.5666 g, 8.323 mmol) were dissolved in DMF (5 mL, 7.567 mmol) and stirred at ambient temperature overnight. The reaction mixture was diluted with H20 (25 mL) and extracted with EtOAc (2 x 25mL). The combined organic phases were washed with brine (25 mL), dried with MgS04, filtered and concentrated to afford the product (1.92 g, 103%) yield). 1H NMR (CDC13) delta 3.66 (s, 3H), 3.57 (s, 2H), 1.15 (s, 6H), 0.87 (s, 9H), 0.02 (s, 6H).

With the rapid development of chemical substances, we look forward to future research findings about 14002-80-3.

Reference:
Patent; ARRAY BIOPHARMA INC.; ALLEN, Shelley; ANDREWS, Steven, W.; BLAKE, James, F.; CONDROSKI, Kevin, R.; HAAS, Julia; HUANG, Lily; JIANG, Yutong; KERCHER, Timothy; KOLAKOWSKI, Gabrielle R.; SEO, Jeongbeob; WO2012/158413; (2012); A2;,
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Electric Literature of 100-37-8 , The common heterocyclic compound, 100-37-8, name is 2-(Diethylamino)ethanol, molecular formula is C6H15NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

260 g of thionyl chloride and 240 g of dichloromethane were added to a 1 L reaction flask to cool down, and a mixed solution of 120 g of diethylaminoethanol and 100 g of dichloromethane was prepared in a 500 ml beaker during the cooling process, when the temperature in the reaction flask was lowered to – 10 C,While maintaining the temperature in the range of -10 C to 20 C, a mixture of diethylaminoethanol and dichloromethane was added dropwise, and after the completion of the dropwise addition, the temperature was raised to 35 C for 2.5 h, and then the dichloromethane was concentrated and concentrated until not. After concentration, the temperature was lowered to 24 C. 220 g of anhydrous methanol was added to the reaction flask and heated to dissolve the solid. After the solid was completely dissolved, the ice brine was cooled to -8 C for 7 h.Filtering to obtain 2-diethylaminochloroethane hydrochloride wet product,After the mother liquor is collected, the methanol is continuously concentrated and recovered, and the residue is subjected to freeze crystallization for 24 hours.The mother liquor product is obtained by suction filtration, and the mother liquor product is recrystallized with methanol.The obtained 2-diethylaminochloroethane hydrochloride is dried at 55-60 C to obtain a dry product.The purity of the liquid phase was determined to be 99.74%, and the molar yield was 98.08%.

The synthetic route of 100-37-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Baoji University of Arts and Sciences; Guo Yaning; (6 pag.)CN108863811; (2018); A;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 599-67-7, name is 1,1-Diphenylethanol, the common compound, a new synthetic route is introduced below. HPLC of Formula: C14H14O

General procedure: A mixture of 1 (2 mmol), 2 (4 or 15 mmol) and NaHSO4/SiO2 (2.1 mmol/g, 1.0 or 2.0g) in DCE (10 mL) was stirred at 80 C for 2 h, and then the used supported reagent was removed by filtration. The filtrate was evaporated to leave crude product, which was purified by column chromatography (hexane/chloroform) to obtain substituted chromans 3.

The synthetic route of 599-67-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Aoyama, Tadashi; Furukawa, Takuya; Hayakawa, Mamiko; Takido, Toshio; Kodomari, Mitsuo; Synlett; vol. 26; 13; (2015); p. 1875 – 1879;,
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Application of 504-63-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 504-63-2, name is 1,3-Propanediol. A new synthetic method of this compound is introduced below.

Synthesis of Intermediate L Compound L was prepared according to the procedure of McDougal, P. G.; Rico, J. G.; Oh, Y.-L; Condon, B. J. Org. Chem., 1986, 51, 3388-3390. To a dried 250 mL RBF under an atmosphere of argon at room temperature was added 100 mL of distilled THF and 2.1 g of sodium hydride (60% dispersion in mineral oil; Aldrich). The mixture was stirred vigorously and 1,3-propanediol (4.0 g, 50 mmol; Aldrich) was added over 10 minutes via syringe. The reaction was allowed to stir for 45 minutes before tert-butyldimethylsilyl chloride (7.9 g, 52.7 mmol; Aldrich) was added portion wise over 5 minutes. The reaction was then allowed to stir for a further 45 minutes at room temperature before being quenched slowly with 20 mL of 10% aqueous sodium carbonate solution. This mixture was then transferred to a separatory funnel. After being vigorously shaken, the biphasic mixture was separated and the aqueous phase was further extracted with two 50 mL portions of ether. The combined organic phases are then dried with sodium sulfate and filtered through a plug of 1 inch of Celite and 1 inch of flash silica (silica gel 60, EMD) via a 100 mL sinter funnel under vacuum into a 500 mL RBF, with the sodium sulfate residue washed with a further 50 mL of ether. The collected solution was then reduced under vacuum on a Buchi rotary evaporator to give compound L, as a light yellow oil in 99% yield and >95% purity. The 1H NMR spectrum in CDCI3 agreed with the previously reported data. (See, McDougal, P. G.; Rico, J. G.; Oh, Y.-L; Condon, B. J. Org. Chem., 1986, 51, 3388-3390.)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,504-63-2, 1,3-Propanediol, and friends who are interested can also refer to it.

Reference:
Patent; PREVACUS, INC.; THE FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC.; LEVY, Daniel, E.; CRAN, John, W.; (93 pag.)WO2016/44558; (2016); A1;,
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