Month: January 2021

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2566-44-1, name is 2-Cyclopropylethanol. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C5H10O

To a solution of triphosgene (68 mg, 0.23 mmol) in dichloromethane (0.5 mL) was added 2-cyclopropylethanol (69 mg, 0.80 mmol). After the solution was stirred for 45 min at ambient temperature N,N-diisopropyl ethyl amine (156 mul, 0.912 mmol) and rac-{4-[(3S,4R)-3-(3,4-dichloro-phenyl)-4-methylamino-pyrrolidine-1-carbonyl]-piperidin-1-yl}-(1-methyl-cyclopropyl)-methanone (50 mg, 0.11 mmol) were added and the solution was stirred for 3 d at ambient temperature. It was diluted with ethyl acetate (15 mL) and washed with aqueous sodium carbonate (1 M, 15 mL) and brine (15 mL). The aqueous layers were extracted with ethyl acetate, dried over sodium sulfate and concentrated. Purification by chromatography (SiO2, ethyl acetate_methanol=100:0 to 80:20) afforded the title compound (59 mg, 94%) as an off-white foam. MS m/e: 550.3 [M]+.

With the rapid development of chemical substances, we look forward to future research findings about 2566-44-1.

Reference:
Patent; Knust, Henner; Koblet, Andreas; Nettekoven, Matthias; Ratni, Hasane; Riemer, Claus; Vifian, Walter; US2011/144081; (2011); A1;,
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Electric Literature of 16308-92-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 16308-92-2 as follows.

(2,4-dimethylphenyl)methanol (1.72 g, 12.7 mmol) and triethyl amine (5.1 mL, 38.1 mmol) were dissolved in dichloromethane (50 mL) and the solution was cooled to 0C. A solution of methanesulfonyl chloride (1.18 mL, 15.2 mmol) in dichloromethane (20 mL)was added dropwise for a period of 20 minutes. The reaction mixture was thereafter allowed to reach room temperature, and was stirred at that temperature for 2 hours. The excess of methanesulfonyl chloride wasquenched by addition of methanol (5.0 mL) and stirring for an additional 10 minutes. The reaction mixture was extracted with dilute HC1 (5%, 100 mL), and thereafter washed with sodium bicarbonate (5% solution, 2×50 mL) and with brine (2×100 mL). The dichloromethane phased was dried over anhydrous sodium sulfate and evaporated to dryness,yielding 2.57 g of the title product, which was used without further purification in the subsequent step.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,16308-92-2, its application will become more common.

Reference:
Patent; F2G LIMITED; SIBLEY, Graham Edward Morris; MALMSTROeM, Lars Jonas; LARSSON, Johanna Maria; (212 pag.)WO2017/9651; (2017); A1;,
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Application of 35364-79-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 35364-79-5, name is 2-(3,4-Dichlorophenyl)ethanol. A new synthetic method of this compound is introduced below.

a. 2-(3,4-Dichlorophenyl)ethyl methansulfonate Using the method of Example 1a, but substituting 3,4-dichlorophenethyl alcohol for 3-methoxyphenethyl alcohol, the title product was obtained as a yellow oil in 88% yield.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,35364-79-5, 2-(3,4-Dichlorophenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; McNeilab, Inc.; US4729994; (1988); A;; ; Patent; McNeilab, Inc.; EP256888; (1991); B1;,
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Electric Literature of 112-27-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 112-27-6, name is 2,2′-(Ethane-1,2-diylbis(oxy))diethanol, molecular formula is C6H14O4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

250mL single-neck flask was added triethylene glycol (19.69g, 131.13mmol), solution of p-toluenesulfonyl chloride (5.00g triethylamine (7.96g, 78.68mmol) and dichloromethane (50mL), ice-cooled, 26.23 mmol) was dissolved in dichloromethane (50 mL) of. After completion of the dropwise addition, the reaction system was transferred to room temperature overnight. The solvent was removed by rotary evaporation, the residue was added methylene chloride (a 500 mL) was dissolved, washed with water (a 500 mL) and saturated brine (300mL), dried over anhydrous sodium sulfate. Filtered and the solvent was removed by rotary evaporation to give a colorless oil 6.70g, yield 83.94%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 112-27-6, 2,2′-(Ethane-1,2-diylbis(oxy))diethanol.

Reference:
Patent; Guangdong East Sunshine Pharmaceutical Co., Ltd.; Wang, Xiaojun; Yang, Xinye; Zhou, Pingjian; Yang, Chuanwen; Lin, Jihua; Xiong, Shaohui; Zhang, Yingjun; Xiao, Ying; Wang, Hui; Cao, Shengtian; Wu, Fangyuan; Ouyang, Luo; (74 pag.)CN105524053; (2016); A;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 32328-03-3, name is Diethyl 3-hydroxyglutarate. A new synthetic method of this compound is introduced below., Recommanded Product: 32328-03-3

1. Synthesis of 1,3,5-Pentanetriol (II)Diethyl 3-hydroxyglutarate (I, 1.0 g, 4.9 mmol) in anhydrous THF (10 mL) was added dropwise to a suspension of LiAlH4 in anhydrous THF (110 mL) under nitrogen with a cold water bath. Upon addition, the bath was removed and the suspension was stirred at room temperature for 2 days. The resulting mixture was quenched by adding 13 mL of brine very slowly with an ice-water bath. A white suspension was resulted, and the mixture was stirred at room temperature overnight. The solid was filtered, and washed with THF. The filtrate and wash were combined, and solvent evaporated to give 0.70 g of pale oil. Column chromatography of the crude product (230-400 mesh SiO2, 100 mL, 0-12% methanol gradient in chloroform) afforded 0.54 g of II as colourless oil.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 32328-03-3, Diethyl 3-hydroxyglutarate.

Reference:
Patent; Tekmira Pharmaceuticals Corporation; Manoharan, Muthiah; Jayaraman, Muthusamy; Rajeev, Kallanthottathil G.; Eltepu, Laxman; Ansell, Steven; Chen, Jianxin; US9186325; (2015); B2;,
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Application of 932-01-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.932-01-4, name is 4,4-Dimethylcyclohexanol, molecular formula is C8H16O, molecular weight is 128.21, as common compound, the synthetic route is as follows.

To a solution of 7-nitroisoquinolin-l(2H)-one (100 mg, 0.52 mmol) and 4,4- dimethylcyclohexanol (100 mg, 0.79 mmol) in THF (2 mL) were added PPh3 (342 mg, 1.30 mmol) and diisopropylazodicarboxylate (263 mg, 1.30 mmol) and the reaction mixture was heated at reflux for 6 h. Then the reaction mixture was quenched with water and was extracted with EtOAc. The organic layer was washed with brine, separated, dried, filtered and concentrated. The residue was purified by column chromatography to afford 100 mg of the title product. MS (m/z): 301 (M+H)+.

Statistics shows that 932-01-4 is playing an increasingly important role. we look forward to future research findings about 4,4-Dimethylcyclohexanol.

Reference:
Patent; GLENMARK PHARMACEUTICALS S.A.; GHARAT, Laxmikant Atmaram; BANERJEE, Abhisek; KHAIRATKAR-JOSHI, Neelima; KATTIGE, Vidya Ganapati; WO2014/167444; (2014); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 20605-01-0, name is Diethyl 2,2-bis(hydroxymethyl)malonate, the common compound, a new synthetic route is introduced below. Recommanded Product: Diethyl 2,2-bis(hydroxymethyl)malonate

DIETHYL 2-ACETYLOXYMETHYL-2-HYDROXYMETHYLMALONATE (5); Diethyl 2-(tert-butyldimethylsilyloxymethyl)-2-hydroxymethylmalonate (5a). Diethyl 2,2-bis(hydroxymethyl)malonate (28.3 mmol; 6.23 g) was coevaporated twice from dry pyridine and dissolved in the same solvent (20 mL). tert-Butyldimethylsilyl chloride (25.5 mmol; 3.85 g) in dry pyridine (10 mL) was added portionwise. The reaction was allowed to proceed for 4 days. The mixture was evaporated to a solid foam, which was then equilibrated between water (200 mL) and DCM (4¡Á100 mL). The organic phase was dried on Na2SO4. The product was purified by silica gel chromatography eluting with 10% ethyl acetate in DCM. The yield was 78%. 1H NMR (CDCl3) delta 4.18-4.25 (m, 4H, OCH2Me), 4.10 (s, 2H, CH2OSi), 4.06 (s, 2H, CH2OH), 2.63 (br s, 1H, OH), 1.26 (t, J=7.0 Hz, 6H, OCH2CH3), 0.85 (s, 9H, Si-SMe3), 0.05 (s, 6H, Me-Si). 13C NMR (CDCl3) delta 169.2 (CO), 63.3 (CH2OH), 62.8 (CH2OSi), 61.6 (spiro C), 61.4 (OCH2Me), 25.6 [C(CH3)3], 18.0 (Si-CMe3), 14.0 (OCH2CH3), -3.6 (Si-CH3). MS [M+H]+obsd. 335.7, calcd. 335.2; [M+Na] obsd. 357.6, calcd. 357.2.

The synthetic route of 20605-01-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Alios BioPharma Inc.; US2009/181921; (2009); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5653-67-8, name is (2,3-Dimethoxyphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of (2,3-Dimethoxyphenyl)methanol

A. 2,3-Dimethoxybenzyl chloride Thionyl chloride (288 g) is added over 1.5 hour to a stirred solution of 2,3-dimethoxybenzyl alcohol (400 g) and 2,6-lutidine in methylene chloride (2 l). The reaction mixture is then stirred for 30 minutes after which it is washed with 2 N hydrochloric acid (7*1 l) and then with water. The organic layer is separated, dried (MgSO4) and evaporated to give a residue, which upon distillation yields 3,4-dimethoxybenzyl chloride (375 g), b.p. 145-150 C. at 20-25 nm (waterpump vacuum). The material solidifies on standing.

With the rapid development of chemical substances, we look forward to future research findings about 5653-67-8.

Reference:
Patent; Merrell-Toraude et Cie; US4342780; (1982); A;,
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Electric Literature of 627-30-5, Adding some certain compound to certain chemical reactions, such as: 627-30-5, name is 3-Chloropropan-1-ol,molecular formula is C3H7ClO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 627-30-5.

Example 5: Production of polymer particles by treating a mixture of azide-modified PAA and alkyne-modified PAA with acid; Synthesis of 3-azidopropanol: In a 100 ml_ round bottom flask, liquid 3- chloropropanol (10.0 g, 1.0 equiv), solid sodium azide (17.19 g, 2.5 equiv) were reacted in DMF for 40 hours at 100 0C. The reaction mixture was cooled to room temperature, poured into a reparatory funnel and extracted with diethyl ether (300 ml_) and brine solution (500 ml_). The organic layer was separated and dried over MgSO4. Rotary evaporation removed the diethyl ether solvent at room temperature and yielded crude 3-azidopropanol (12.5 g). 1H-NMR (delta, ppm) CDCI3: 3.76 – 3.73 (t, 2H, HOCH2CH2CH2N3), 3.46 – 3.43 (t, 2H, HOCH2CH2CH2N3), 2.09 (br-s, 1 H, OH), 1.86 – 1.80 (m, 2H, HOCH2CH2CH2N3). IR neat (cm”1): 2100 (N=N=N).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 627-30-5, 3-Chloropropan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; VIVE NANO, INC.; LI, Fugang; PHAM, Hung; ANDERSON, Darren, J.; WO2010/35118; (2010); A1;,
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Adding a certain compound to certain chemical reactions, such as: 33524-31-1, (2,5-Dimethoxyphenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C9H12O3, blongs to alcohols-buliding-blocks compound. Computed Properties of C9H12O3

General procedure: The benzyl alcohol derivatives (1 mmol), catalyst 1 or 3 (2 mol%),base (5 mol%) and toluene or p-xylene (20 mmol) were added to aSchlenk tube under argon or nitrogen atmosphere. The mixture wasstirred magnetically at reflux temperature. The yields of the prod-ucts were analyzed by GC chromatography using chlorobenzene asan internal standard.

The synthetic route of 33524-31-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Thangavel, Saravanan; Boopathi, Subramaniam; Mahadevaiah; Kolandaivel, Ponmalai; Pansuriya, Pramod B.; Friedrich, Holger B.; Journal of Molecular Catalysis A: Chemical; vol. 423; (2016); p. 160 – 171;,
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