Month: January 2021

Related Products of 1875-88-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1875-88-3, name is 2-(4-Chlorophenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

Step a. 1-chloro-2-(4-chlorophenyl)ethane. To a solution of 4-chlorophenethyl alcohol (5 ml, 37 mmol) and pyridine (3.0 ml, 37.0 mmol) in a two-necked flask, equipped with a dropping funnel and a reflux condenser fitted with calcium chloride drying tube, was added thionyl chloride (5.39 ml, 74.0 mmol) dropwise over 1 h. The reaction was heated at reflux for 1.5 h before being cooled in an ice-bath. This led to the precipitation of a white solid which was filtered off rapidly and washed with a small quantity of cold diethyl ether. The organic material was then washed cautiously with water (1*30 ml), 2N sodium hydroxide solution (2*30 ml) and water (1*30 ml), dried over magnesium sulfate, filtered and the solvent evaporated to give the desired product as a pale yellow oil (5.73 g): 1H NMR (300 MHz, CDCl3) 7.29 (2H, d), 7.16 (2H, d), 3.70 (2H, t), 3.05 (2H, t).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1875-88-3, 2-(4-Chlorophenyl)ethanol.

Reference:
Patent; James Black Foundation Limited; US6355665; (2002); B1;,
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Related Products of 20017-67-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 20017-67-8, name is 3,3-Diphenyl-1-propanol. A new synthetic method of this compound is introduced below.

Methanesulfonyl chloride (2.16 g, 18.8 mmol) was slowly added to an ice-cooled solution of 3,3-diphenylpropan-1 -ol ( 4.0 g, 18.8 mmol) and thethylamine (5.7 g, 56.5 mmol) in dichloromethane (18 ml_). The mixture was then allowed to warm to room temperature and stirred overnight. It was then diluted with water and dichloromethane. The phases were separated and the aqueous phase was re- extracted twice with dichloromethane. The combined organic phases were dried over Na2SO4 and concentrated to dryness, providing the desired compound as a crude that was directly used without further purification.1H NMR (300 MHz, CDCI3) delta: 2.53 (m, 2H), 2.91 (s, 3H), 4.13-4.21 (m, 3H), 7.2- 7.35 (m, 10H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,20017-67-8, its application will become more common.

Reference:
Patent; PALAU PHARMA, S. A.; CARCELLER GONZALEZ, Elena; VIRGILI BERNADO, Marina; WO2010/43633; (2010); A1;,
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Related Products of 61487-25-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.61487-25-0, name is (2-Amino-3-chlorophenyl)methanol, molecular formula is C7H8ClNO, molecular weight is 157.6, as common compound, the synthetic route is as follows.

Example 84 – Preparation of 2-benzyloxymethyl-6-chloro aniline This material was prepared from 2-amino-3-chlorobenzyl alcohol and benzyl bromide by the general procedure outlined in Example 82. The product was purified by Kugelrohr distillation to yield an oil, bp 118-125C (0.1 mm). The product was characterized by IR and 1H NMR spectroscopy.

The chemical industry reduces the impact on the environment during synthesis 61487-25-0, I believe this compound will play a more active role in future production and life.

Reference:
Patent; THE DOW CHEMICAL COMPANY; EP142152; (1991); B1;,
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Adding a certain compound to certain chemical reactions, such as: 14002-80-3, Methyl 3-hydroxy-2,2-dimethylpropanoate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: Methyl 3-hydroxy-2,2-dimethylpropanoate, blongs to alcohols-buliding-blocks compound. Recommanded Product: Methyl 3-hydroxy-2,2-dimethylpropanoate

A mixture of methyl 2,2-dimethyl-3-hydroxypropionate (100 g, 0.76 mol), 4-toluenesulfonyl chloride (151 g, 0.80 mol), 4-dimethylaminopyridine (4.6 g, 0.038 mol), and pyridine (200 mL) was stirred for 20 hrs and then was diluted with 200 mL toluene, stirred for 30 min and filtered. The filtrate was concentrated to 250 mL at aspirator pressure, diluted with 100 mL toluene, filtered, and concentrated. The residue was suspended in 200 mL hexanes, and the solvent was removed at aspirator pressure to yield the title compound (235 g, 100%) contaminated by a trace of toluenesulfonyl chloride.

The synthetic route of 14002-80-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Garst, Michael E.; Dolby, Lloyd Jay; Esfandiari, Shervin; MacKenzie, Vivian Rose; Avey JR., Alfred Arthur; Muchmore, David Charles; Cooper, Geoffrey Kenneth; Malone, Thomas C.; US2005/38076; (2005); A1;,
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Electric Literature of 1454-84-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1454-84-8, name is 1-Nonadecanol. A new synthetic method of this compound is introduced below.

General procedure: A mixture of succinic anhydride (1.0 eq) and dry alcohol (1 eq) in toluene (4 mL) was heated at reflux 2.5 h. The toluene was removed under reduced pressure and the residue was taken up in water, and the solution was extracted with dichloromethane, dried (MgSO4), and evaporated to afford monoalkylsuccinic acid. A solution of monoalkyl succinic acid (1.2 eq) and thionyl chloride (1.4 eq) in benzene (5 mL) was refluxed for 3 h. Subsequently, the majority of the SOCl2 and benzene were removed by distillation. The mixture was cooled down to room temperature and dried under a vacuum to give a crude chlorocarbony-alkyl ester. A solution of chlorocarbonyl-alkyl ester in dichloromethane (5 mL) was added to a round flask containing 14 (1 eq) by cannula, and subsequently added pyridine (1.4 eq). The resulting solution was stirred at room temperature overnight, and quenched by adding water. The solution was extracted with ethyl acetate, dried (MgSO4), and evaporated to give a residue which was purified by column chromatography (Al2O3), eluting by ethyl acetate /hexane (1:15) to provide 25-43.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1454-84-8, its application will become more common.

Reference:
Article; Yin, Kai-Hao; Hsieh, Yi-Han; Sulake, Rohidas S.; Wang, Su-Pei; Chao, Jui-I.; Chen, Chinpiao; Bioorganic and Medicinal Chemistry Letters; vol. 24; 22; (2014); p. 5247 – 5250;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 22348-44-3, name is trans-4-(Methylamino)cyclohexanol. A new synthetic method of this compound is introduced below., COA of Formula: C7H15NO

To a solution of compound 84-2 (140 mg, 1.085 mmol) in DCM (4 mL) was added Boc anhydride (473 mg, 2.170 mmol) and TEA (329 mg, 3.255 mmol), and the reaction solution was stirred at 20 C. for 30 min. After of TLC indicated the reaction was complete, the reaction was quenched with water (30 mL¡Á1), and the aqueous phase was extracted with EtOAc (50 mL¡Á2). Then the organic phases were combined, dried over anhydrous Na2SO4, filtered and evaporated to give compound 84-3 (yellow oil, 180 mg, Yield 72.4%). 1H NMR (400 MHz, CDCl3): delta ppm 6.31 (br. s., 1H), 5.14-5.21 (m, 1H), 4.97 (d, J=6.24 Hz, 2H), 4.48 (d, J=7.09 Hz, 2H), 3.36 (t, J=11.49 Hz, 1H), 2.85 (t, J=11.62 Hz, 1H), 2.18 (br. s., 1H), 1.89 (br. s., 1H), 1.60-1.66 (m, 1H), 1.47 (t, 3H), 1.44 (s, 9H). (1362) LCMS (ESI) m/z: 230 (M+1)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 22348-44-3, trans-4-(Methylamino)cyclohexanol.

Reference:
Patent; Hubei Bio-Pharmaceutical Industrial Technological Institute Inc.; Humanwell Healthcare (Group) Co., Ltd.; Wang, Xuehai; Wu, Chengde; Xu, Yong; Shen, Chunli; Li, Li’e; Hu, Guoping; Yue, Yang; Li, Jian; Guo, Diliang; Shi, Nengyang; Huang, Lu; Chen, Shuhui; Tu, Ronghua; Yang, Zhongwen; Zhang, Xuwen; Xiao, Qiang; Tian, Hua; Yu, Yanping; Chen, Hailiang; Sun, Wenjie; He, Zhenyu; Shen, Jie; Yang, Jing; Tang, Jing; Zhou, Wen; Yu, Jing; Zhang, Yi; Liu, Quan; (251 pag.)US2017/313683; (2017); A1;,
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Reference of 3344-77-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3344-77-2, name is 12-Bromododecan-1-ol, molecular formula is C12H25BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(a) 2-(12-Bromododecyloxy)tetrahydropyran 12-Bromo-dodecan-1-ol (5.12 g, 19.3 mmol) was added to a vigorously stirred solution of dihydropyran (2.1 mL, 23.2 mmol) and Amberlyst HI5 (0.25 g, Aldrich D10,620-8) in hexane (100 mL). After 3 hours dihydropyran (2.1 mL) was added and the solution stirred for a further 15 hours. The mixture was then filtered, and the filtrate concentrated in vacuo and chromatographed graphed on silica gel, eluding with 2percent ethyl acetate in hexane to give the title compound, (a), 8.02 g (75percent), as an oil.

According to the analysis of related databases, 3344-77-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Warner-Lambert Company; US5073565; (1991); A;,
Alcohol – Wikipedia,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 597-31-9, name is 3-Hydroxy-2,2-dimethylpropanal. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 3-Hydroxy-2,2-dimethylpropanal

EXAMPLE 2Purification of HPA A complete mixture was prepared at 55C by adding 2505 parts of water into 835 parts of the crude HPA obtained in Reference Example 1. The mixture was gradually cooled from 55C to 32C over 5 h under stirring and then kept at 32C for one hour. The resultant crystals were separated by solid-liquid separation using a top-discharge centrifugal separator and then washed with water, to obtain HPA having a purity of 96.5% by weight in 60% recovery. The water content was 12% by weight and the remaining TEA content was 0.01% by weight. Synthesis of SPG from Purified HPA Into a solution of 95 parts of PE in 1200 parts of water, were added 5 parts of p-toluenesulfonic acid (PTSA) and 26 parts of SPG crystals obtained in Reference Example 2 as seed crystals (1.7% by weight of the total feed amount into the reaction system). Then, an aqueous solution of the purified HPA prepared by dissolving 160 parts of the purified HPA in 65 parts of water under heating at 80C was further added dropwise over 3.5 h. The SPG content X was 14.8% by weight. The pH of the reaction liquid at the initiation of reaction was 1.8, and the reaction temperature was 90C. After the dropwise addition, the reaction liquid was aged for 2 h while maintaining the temperature at 90C. The pH of the reaction production solution at the completion of reaction was 1.8. After the aging, the reaction product solution was separated into wet SPG and 1240 parts of reaction mother liquor by solid-liquid separation. The wet SPG was washed with 460 parts of water and then dried, to obtain 147 parts of SPG crystals. The yield of SPG was 56.8 mol% based on the charged PE, and the purity of SPG crystals was 99.9% by weight when analyzed by GC. The average particle size of SPG crystals was 23 um when measured on a water dispersion of SPG crystals by using a wet particle size distribution analyzer after exposing the water dispersion to ultrasonic wave for 10 min. The amount of waste water (reaction mother liquor + recovered washings + recovered water in drying) was 1780 parts. During the solid-liquid separation by filtration through a glass filter under reduced pressure, no crack occurred on the cake. The liquid content of SPG cake immediately after the filtration was 37% by weight. First Recycling Reaction Next, a first recycling reaction was performed in the same manner as in the above synthesis except for making 1200 parts of the reaction mother liquor (85% by weight of the whole amount) and 95 parts of PE into a solution under heating and using 0.7 part of PTSA and 240 parts of the aqueous solution of the purified HPA. The yield of dried SPG was 96.5 mol% and the purity was 99.8% by weight. The average particle size after exposed to ultrasonic wave was 22 um. During the solid-liquid separation by filtration through a glass filter under reduced pressure, no crack occurred on the cake. The liquid content of SPG cake immediately after the filtration was 37% by weight. Second Recycling Reaction Next, a second recycling reaction was performed in the same manner as in the first recycling reaction except for using 1100 parts of the reaction mother liquor (83% by weight of the whole amount) and 100 parts of water. The yield of dried SPG was 94.6 mol% and the purity was 99.8% by weight. The average particle size after exposed to ultrasonic wave was 22 um. During the solid-liquid separation by filtration through a glass filter under reduced pressure, no crack occurred on the cake. The liquid content of SPG cake immediately after the filtration was 37% by weight. Third and Subsequent Recycling Reactions The above procedure was repeated to perform the recycling reactions up to 10 cycles. The yield of SPG was 94.0 mol%, the purity was 99.7% by weight, and the particle size after exposed to ultrasonic wave was 20 um or more, each in average of third to tenth recycling reactions. The amount of waste water was 584 parts in average. During the solid-liquid separation by filtration through a glass filter under reduced pressure, no crack occurred on the cake. The liquid content of SPG cake immediately after the filtration was 42% by weight in average.

With the rapid development of chemical substances, we look forward to future research findings about 597-31-9.

Reference:
Patent; MITSUBISHI GAS CHEMICAL COMPANY, INC.; EP1598357; (2005); A1;,
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Reference of 3250-73-5 , The common heterocyclic compound, 3250-73-5, name is 2-(2-Ethoxyphenoxy)ethanol, molecular formula is C10H14O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Afterthe pyridine (200ml) was added to obtained 2 – (2- ethoxyphenoxy) ethanols (50.0g,0.274mol, 1.0eq) at 1 step and it altogether dissolved it cooled at 0. Methanesulfonyl chlorides(35.0ml, 0.453mol, 1.65eq) were dipped from the gradually to the cooledsolution and it was stirred for 1 hour while it heated to the slowly to the room temperature (20). The solid which wasgenerated after it dipped the water (350ml) as the gradually after it cooledthe above-mentioned stirred solution at 0 was filtered and 2 – (2- ethoxyphenoxy) ethylmethane sulfonate was obtained (62g, and the yield 87%). 2-(2-) NMR . Theobtained NMR peak of 2 – (2- ethoxyphenoxy) ethyl methane sulfonate showed uplike the next.

The synthetic route of 3250-73-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Boryung Pharmaceutical Co., Ltd; Kim, Ji Han; Myung, Jae Hyok; Lee, Jun Kwang; Sun, Yong Ho; Kim, Hak Do; (20 pag.)KR101525493; (2015); B1;,
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Related Products of 756520-66-8, Adding some certain compound to certain chemical reactions, such as: 756520-66-8, name is 1-(2,6-Dichloro-3-fluorophenyl)ethanol,molecular formula is C8H7Cl2FO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 756520-66-8.

1 -(2,6-dichloro-3- fluorophenyl)ethanol (5.2 g, 24.9 mmol), methanesulfonyl chloride (6.3 g, 55 mmol, 2.2 eq), and triethylamine (6.1 g) were stirred in 50 ml of DCM and 12 ml of DMF at room temperature overnight. Water and DCM were added, and the layers were separated. The aqueous layer was extracted with DCM. The combined organic layers were dried, evaporated and chromatographed (EtOAc/Hexanes 1 : 10) to give an oil, 5.11 g, in 71% yield.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 756520-66-8, 1-(2,6-Dichloro-3-fluorophenyl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ARIAD PHARMACEUTICALS, INC.; QI, Jiwei; WANG, Yihan; LI, Feng; SHAKESPEARE, William, C.; KOHLMANN, Anna; DALGARNO, David, C.; ZHU, Xiaotian; WO2010/68292; (2010); A1;,
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