Month: January 2021

Related Products of 111-45-5 , The common heterocyclic compound, 111-45-5, name is 2-(Allyloxy)ethanol, molecular formula is C5H10O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

10072] In a one-liter flask equipped with a stirring device, a dimroth condenser, a thermometer and a dropping thnnel, put were 38.25 g (0.375 mol) of ethylene glycol monoallyl ether represented by the following formula (7) and 100 g oftoluene, and heated to 70 degrees C. 0.38 Gram of a solution of a catalyst, complex of alkali-neutralized chloroplatinic acid with vinyl siloxane, in toluene, containing 0.5% of platinum, was added in the flask. Then, 185 g (0.25 mol) of the compound represented by the aforesaid formula (6) was added dropwise in the flask with the dropping funnel over one hout The reaction mixture was held at 100 degrees C. for one hour and, then, analyzed in GC. The peak of the compound represented by the aforesaid formula (6) disappeared, which means that the reaction completed. 100 Grams of ion exchanged water were added to the reaction mixture with stirring to wash it and, then, lefi standing to cause phase separation. The aqueous phase containing the excessive ethylene glycol monoallyl ether was removed. The organic phase was similarly washed twice with each 100 g of ion exchanged water and, then, the toluene in the organic phase was stripped off under a reduced pressure to obtain 193.7 g (0.23 mol) of a colorless and transparent liquid, silicone compound representedby the following formula (8). The yield was 92%. The ratio of the silicone compound represented by the following formula (8) in the obtained product was 98.1 mass %, as determined in GC.

The synthetic route of 111-45-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SHIN-ETSU CHEMICAL CO., LTD.; KUDO, Muneo; US2015/361114; (2015); A1;,
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Reference of 27489-62-9, Adding some certain compound to certain chemical reactions, such as: 27489-62-9, name is trans-4-Aminocyclohexanol,molecular formula is C6H13NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 27489-62-9.

Preparation of trans-4-(3-(5,6,7-trimethoxybenzo[b]thiophen-2-yl)imidazo[1,2-b]pyridazin-6-ylamino)cyclohexanol To a solution of 6-chloro-3-(5,6,7-trimethoxybenzo[b]thiophen-2-yl)imidazo[1,2-b]pyridazine (50 mg, 0.133 mmol, 1.0 equiv) in DMSO (2.0 mL) was added p-toluene sulfonic acid monohydrate (25 mg, 0.144 mmol, 1.0 equiv) and amine (0.532 mmol, 4.0 equiv) and heated to 100 C. for 24 h. The reaction mixture was diluted with water and extracted with ethyl acetate. Purification by column chromatography using 5% methanol in dichloromethane elution 36 mg of the brown solid, 60%. Compound 179 was physically characterized by electrospray ionization mass spectrometry. Structures and molecular masses are given below in Table 35-b.

According to the analysis of related databases, 27489-62-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Califia Bio, Inc.; GOODFELLOW, VAL S.; NGUYEN, THONG X.; RAVULA, SATHEESH B.; GELBARD, HARRIS A.; US2014/256733; (2014); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 534-03-2, name is 2-Aminopropane-1,3-diol, molecular formula is C3H9NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of 2-Aminopropane-1,3-diol

(1) N-(4-Phenoxybenzenesulfonyl)serinol After triethylamine (10.12 g, 100 mmol) was added dropwise to a solution of serinol (3.64 g, 40 mmol) in a mixture of dioxane (100 ml) and water (200 ml), the mixture was stirred at room temperature for 30 minutes.. To the reaction mixture, a solution of 4-phenoxybenzenesulfonyl chloride (10.75 g, 40 mmol) in dioxane (100 ml) was added dropwise and this was stirred for 3 hours.. Most of the solvent was evaporated under reduced pressure and the residue was extracted with ethyl acetate.. The organic layer was washed with water, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to afford the desired compound (10.62 g, yield 82%) as a white powder. 1H-Nuclear magnetic resonance spectrum (400 MHz, CDCl3-DMSO-d6) delta ppm: 7.84 (2H, d, J=8 Hz), 7.41 (2H, t, J=8 Hz), 7.22 (2H, t, J=7 Hz), 7.09-7.01 (4H, m), 6.69 (1H, d, J=7 Hz), 4.10-4.06 (1H, m), 3.63-3.45 (4H, m).

With the rapid development of chemical substances, we look forward to future research findings about 534-03-2.

Reference:
Patent; Sankyo Company, Limited; US6673804; (2004); B1;,
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Reference of 127-66-2 ,Some common heterocyclic compound, 127-66-2, molecular formula is C10H10O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: Catalyst by about 5 mg, propargylic alcohols 4.95 mmol inwater 0.5-1 mL and secondary amines by around 5 mmolwere mixed with a Schlenk tube that equipped to a stir bar.After that the apparatus was clean with carbon dioxide formore than two times, the blend was stirred under the temperatureof 50 C and pressure of 1.5 bar for carbon dioxidefor the desired time. When the considered reaction finished,the mixture was adapted by diethyl ether (3-15 mL). Theupper layers were gathered and dried by vacuuming to obtainthe crude yields that might be purified using more column chromatography onto silica gel by petroleum ether/ethylacetate (100:1-20:1).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,127-66-2, its application will become more common.

Reference:
Article; Fan, Liqun; Wang, Jinhu; Zhang, Xianman; Sadeghzadeh, Seyed Mohsen; Zhiani, Rahele; Shahroudi, Mina; Amarloo, Fatemeh; Catalysis Letters; vol. 149; 12; (2019); p. 3465 – 3475;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 27489-62-9, name is trans-4-Aminocyclohexanol. A new synthetic method of this compound is introduced below., category: alcohols-buliding-blocks

Step 1: trans (4-Hydroxy-cyclohexyl)-carbamic acid benzyl ester To an ice cold mixture of 50 g of trans 4-aminocyclohexanol in 500 mL of ethyl acetate and 500 mL of THF was added 200 mL of saturated sodium carbonate and the 65 mL of benzyl chloroformate drop-wise over 20 min. The mixture was allowed to warm and stir overnight and the precipitated product collected by filtration and washed with 200 mL of water. After drying under vacuum the white crystalline product weighed 84 g. The combined filtrates were shaken, separated and the aqueous layer extracted with 3*100 mL of ethyl acetate. The combined ethyl acetate extracts were dried over magnesium sulfate and concentrated under reduced pressure. Trituration with ether-hexane gave an additional 35.5 g of product as a white crystalline solid. MS (m+1)=250.4; 1H NMR (400 MHz, CDCl3) 7.4-7.3 (m, 5H), 5.1 (s, 2H), 4.6 (s, 1H), 3.6 (m, 1H), 3.5 (m, 1H), 2.0 (dd, 4H), 1.6 (d, 1H), 1.4 (dd, 2H), 1.2 (dd, 2H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 27489-62-9, trans-4-Aminocyclohexanol.

Reference:
Patent; Thompson, Wayne; Young, Steven D.; Phillips, Brian T.; Munson, Peter; Whitter, Willie; Liverton, Nigel; Dieckhaus, Christine; Butcher, John; McCauley, John A.; McIntyre, Charles J.; Layton, Mark E.; Sanderson, Philip E.; US2005/54658; (2005); A1;,
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Synthetic Route of 20017-67-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 20017-67-8, name is 3,3-Diphenyl-1-propanol. This compound has unique chemical properties. The synthetic route is as follows.

Step 1. Preparation of difluoroacetic acid, O-(3,3-diphenyl-propyl) ester. [0299] Dicyclohexylcarbodiimide (12.6 g, 62.4 mmol) is added portionwise with stirring to a solution of difluoroacetic acid (4.0 g, 4.0 mL, 62.4 mmol), 3,3-diphenyl-1-propanol (14.4 g, 13.8 mL, 68.4 mol) and 4-dimethylaminopyridine (732 mg, 6.2 mmol) in ethyl ether (180 mL) at 0-5 C. The reaction mixture is allowed to warm up to r.t., and stirred at r.t. overnight. The precipitated urea by-product is filtered off and washed with excess ethyl ether. The combined filtrates are evaporated under vacuum, and the residue is purified by silica gel flash chromatography (eluent: 5% ethyl ether in hexanes). White crystalline solid (17.3 g, 96%). HPLC Rt=7.2. MS (m/z): 291 [M+H]+.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 20017-67-8, 3,3-Diphenyl-1-propanol.

Reference:
Patent; Gordeev, Mikhail F.; Renslo, Adam; Luehr, Gary W.; Lam, Stuart; Westlund, Neil E.; Patel, Dinesh V.; US2003/232812; (2003); A1;,
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Synthetic Route of 589-98-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 589-98-0, name is 3-Octanol, molecular formula is C8H18O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 3a: Synthesis of Example 54 [0268] Thionyl chloride (0.29 mL, 4 mmol) was added to a suspension of Intermediate H (0.71 G, 1.0 mmol) and benzotriazole (0.24 G, 2 mmol) in toluene/dichloromethane (1:1, 20 mL), and the obtained mixture was heated under argon at 40 C. for 1 hour. 2-Ethylhexanol was then added, and the mixture was stirred at room temperature for 3 days. The reaction mixture was poured into water (100 mL), neutralized with saturated sodium bicarbonate, stirred for 30 minutes and extracted with dichloromethane (2¡Á100 mL). The extract was dried over magnesium sulfate, the volatiles were removed under reduced pressure and the residue was chromatographed (silica gel, hexane/dichloromethane 1:2). The fractions containing a fluorescent material were combined, the solvent was evaporated and the residue was dried in a vacuum oven to provide chromophore Example 54 (661, mg, 71% yield) as an orange glassy foam. 1H NMR (400 MHz, CDCl3): delta 7.93 (d, 4H, J=8.8 Hz), 7.90 (d, 4H, J=8.8 Hz), 7.78 (s, 2H), 7.35 (dd, 4H, J=7.3 and 8.4 Hz), 7.28 (d, 4H, J=8.5 Hz), 7.22 (dd, 4H, J=1.5 and 8.8 Hz), 7.16 (tt, 2H, J=7.4 and 1.1 Hz), 7.12 (d, 4H, J=8.5 Hz), 4.20 (m, 4H), 1.69 (m, 2H), 1.44-1.30 (m, 16H), 0.94 (t, 6H, J=7.3 Hz), 0.89 (t, 6H, J=7.3 Hz). UV-vis spectrum: lambdamax=442 nm (dichloromethane), 446 nm (PVB film). Fluorimetry: lambdamax=606 nm (dichloromethane), 558 nm (PVB film).

According to the analysis of related databases, 589-98-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NITTO DENKO CORPORATION; RACHWAL, STANISLAW; WANG, PENG; RACHWAL, BOGUMILA; ZHANG, HONGXI; YAMAMOTO, MICHIHARU; US2013/74927; (2013); A1;,
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Related Products of 2854-16-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2854-16-2, name is 1-Amino-2-methylpropan-2-ol, molecular formula is C4H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of [2-(7-methyl-5-{[6-(methylsulfonyl)pyridin-3-yl]oxy}-1H-indol-2-yl)-4,5-dihydro-1,3-thiazol-5-yl]acetic acid (300 mg) and 2-amino-2-methyl-2-propanol (90 mg) in N,N-dimethylformamide (20 mL) were added 1-hydroxybenzotriazole (137 mg) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (194 mg) under ice-cooling, and the mixture was stirred under ice-cooling and then at room temperature for 15 hr. Water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The organic layer was washed with aqueous sodium hydrogen carbonate solution and saturated brine, dried over magnesium sulfate, filtered and concentrated under reduced pressure. The obtained residue was subjected to silica gel column chromatography (ethyl acetate:methanol = 100:0 to 90:10, volume ratio) to give colorless crystals. The obtained crystals were recrystallized from tetrahydrofuran-ethyl acetate to give the title compound (280 mg, yield 81percent) as colorless crystals. melting point 184-186¡ãC. MS 517 (MH+).

According to the analysis of related databases, 2854-16-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Takeda Pharmaceutical Company Limited; EP2371826; (2011); A1;,
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Electric Literature of 1334674-88-2 ,Some common heterocyclic compound, 1334674-88-2, molecular formula is C7H6BrN3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step 3. 2-Bromo-5H-pyrrolo[2,3-b]pyrazine-7-carbaldehyde. To a suspension of (2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)methanol (127 g, 562 mmol) in acetone (2.5 L) was added dropwise Jones reagent (253 mL, 674 mol?2.67 M) below 10 C. After the addition, the resulting mixture was stirred at room temperature for 50 min, which time suspension became clean and then brown solid was precipitated. The three batches were combined for workup together. The reaction mixture was quenched with i-PrOH (60 mL) and filtered, the filter cake was washed with acetone (1 L¡Á2), the combined filtrate was evaporated to give 2-bromo-5H-pyrrolo[2,3-b]pyrazine-7-carbaldehyde (320 g, 84.4%) as a yellow solid. (A stock of Jones reagent (2.67 M) was prepared by carefully adding concentrated H2SO4 (184 mL) to CrO3 (213.6 g) then diluting to 800 mL with H2O.)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1334674-88-2, (2-Bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Thorarensen, Atli; Brown, Matthew Frank; Casimiro-Garcia, Agustin; Che, Ye; Coe, Jotham Wadsworth; Flanagan, Mark Edward; Gilbert, Adam Matthew; Hayward, Matthew Merrill; Langille, Jonathan David; Montgomery, Justin Ian; Telliez, Jean-Baptiste; Unwalla, Rayomand Jal; US2015/158864; (2015); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 22419-35-8, name is 4,4-Difluorocyclohexanol, molecular formula is C6H10F2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of 4,4-Difluorocyclohexanol

To a stirred suspension of (RS)-3-(4-isocyanato-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (110 mg) in THF (1 ml) were added sequentially N,N-diisopropylethylamine (0.13 ml) and 4,4-difluorocyclohexanol (68 mg, CAS 22419-35-8) and the mixture was heated at 110¡ã C. for 18 h. The mixture was then concentrated in vacuo and the residue was purified by column chromatography (SiO2; gradient: heptane/EtOAc) to give (RS)-3-[4-(4,4-difluoro-cyclohexyloxycarbonylamino)-phenyl]-pyrrolidine-1-carboxylic acid tert-butyl ester (20 mg, 12percent) as an off-white solid. MS (ISP): 447.4 ([M+Na]+), 442.4 ([M+NH4]+), 369.2 ([M+H-C4H8]+).

With the rapid development of chemical substances, we look forward to future research findings about 22419-35-8.

Reference:
Patent; Groebke Zbinden, Katrin; Norcross, Roger; Pflieger, Philippe; US2011/152245; (2011); A1;,
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