Reference of 78573-45-2 ,Some common heterocyclic compound, 78573-45-2, molecular formula is C10H11F3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
At room temperature, 15 ml of CHCl,3g 3- (3-trifluoromethylphenyl) propanol was added to a 100 ml reaction flaskA, 2.2 g of triethylamine, stirred and dissolved, and dropwise 2 g of methanesulfonyl chloride. After completion of the dropwise addition, the reaction was carried out for 2 to 3 hours The reaction kettle by adding 9ml 1mol / l of dilute hydrochloric acid stirring, liquid separation. Add 9ml 5% NaHCO3 solution to wash the organic phase, stir Mix and disperse. The organic phase was washed with 9 ml of 25% NaCl, stirred and partitioned. Add anhydrous Na2SO4 to dry and filter. stress reliever The product was distilled to give 5.5 g of a pale yellow liquid in 100% yield.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 78573-45-2, 3-(3-(Trifluoromethyl)phenyl)propan-1-ol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Shanghai Qing Song Pharmaceutical Co., Ltd.; Zhang, Jian; Chen, Xiaona; Zhang, Shubin; Gao, Junfeng; Tan, Zhouhong; (7 pag.)CN106543008; (2017); A;,
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