Adding a certain compound to certain chemical reactions, such as: 702-82-9, 3-Aminoadamantan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 3-Aminoadamantan-1-ol, blongs to alcohols-buliding-blocks compound. name: 3-Aminoadamantan-1-ol
A solution of 66.90 g of 3-amino-1-adamantanol and 340 ml of anhydrous methanol was added successively to 500 ml of 3-necked flask. After stirring, 46.74 g of benzaldehyde was added dropwise, and the mixture was heated and refluxed.After 3 hours, TLC (thin layer chromatography) monitored the reaction until complete conversion of the starting material to form the intermediate.After cooling the reaction system to 0 C, 18.2 g of sodium borohydride was added in portions to the reaction system.After the addition is complete, the reaction is carried out at 0 C to 5 C for 1 to 2 hours.After completion of the reaction by TLC (thin layer chromatography), the solvent was removed by rotary evaporation.To the residue was added 200 ml of water and 300 ml of ethyl acetate, and the organic phase was separated.The organic phase was washed twice with 100 ml of saturated brine, dried over anhydrous sodium sulfate and concentrated to remove the solvent. The crude product was obtained as an oil (118.1 g), which was recrystallized from petroleum ether / ethyl acetate (Volume ratio = 1: 1) to give 95.5 g of a white solid in 92.8% yield
The synthetic route of 702-82-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shandong Weizhi Medicine Industry Co. Ltd.; Wei, yanjun; Wang, hua; Meng, zhoujun; (12 pag.)CN103980175; (2016); B;,
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