The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1117-86-8, name is 1,2-Octanediol. This compound has unique chemical properties. The synthetic route is as follows. Safety of 1,2-Octanediol
General procedure: 2.2.1. General protocol A. The acylation of 1,2-alkanediols withacid chloride1,2-Alkanediol was dissolved in pyridine on slight heating;petroleum ether (PE) was added and the mixture was shaken untilhomogenization. Acid chloride was added dropwise on efcientmagnetic stirring. The mixture was stirred at RT for 0.25-16 hdepending on the target compound. Reaction was monitored byTLC. Methanol (0.5 ml) was added to the mixture when excessof acid chloride was used and stirring was continued for addi-tional 10 min. The reaction mixture was diluted with ethyl acetate(EtOAc) and aqueous NaHCO3 (10%) was added. Following the neutralization the water layer was separated, and the organic layerwashed twice with brine, dried over anhydrous MgSO4, ltered,concentrated and puried by ash chromatography over silica gel.(NB 1,2-Alkanediol bisbutyrates were used in preparative-scalelipase-catalyzed cleavage without previous purication.) The tar-get products were gained in 91-96% yields.;
With the rapid development of chemical substances, we look forward to future research findings about 1117-86-8.
Reference:
Article; Parve, Jaan; Reile, Indrek; Aid, Tiina; Kudrja?ova, Marina; Mueuerisepp, Aleksander-Mati; Vallikivi, Imre; Villo, Ly; Aav, Riina; Pehk, Tonis; Vares, Lauri; Parve, Omar; Journal of Molecular Catalysis B: Enzymatic; vol. 116; (2015); p. 60 – 69;,
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