Synthetic Route of 1805-32-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1805-32-9 as follows.
To a solution of (3,4-dichlorophenyl)methanol (350 mg, 1.98 mmol) in DMF (3 mL) was added sodium hydride (60%, 80 mg, 4.00 mmol) at 0 C. After stirring at 0 C for 30 minutes, 5-chloro-2,4-difluorobenzonitrile (345 mg, 1.99 mmol) was added in portions. The reaction mixture was stirred at room temperature for 6 h, quenched by saturated NH4Cl (10 mL) and extracted with ethyl acetate (5 mL x 3). The combined organic layers were washed with brine, dried over MgSO4, filtered and concentrated in vacuo to afford 5-chloro-4-(3,4-dichlorobenzyloxy)-2-fluorobenzonitrile as a yellow solid. The residue was used in the next step without further purification. LCMS (ESI) m/z: 329.9 [M-H]-
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1805-32-9, its application will become more common.
Reference:
Patent; GENENTECH, INC.; XENON PHARMACEUTICALS INC.; CHEN, Chien-An; CHOWDHURY, Sultan; DEHNHARDT, Christoph Martin; SUN, Shaoyi; WO2014/144545; (2014); A2;,
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