Related Products of 355-80-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.355-80-6, name is 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol, molecular formula is C5H4F8O, molecular weight is 232.0719, as common compound, the synthetic route is as follows.
To a dispersion prepared of 11.22 g (0.2 mol) of KOH and 100 mL of acetonitrile, a portion of 46.4 g (0.2 mol) of 1,1,2,2,3,3,4,4-octafluoropentan-5-ol was added and the mixture was stirred at r.t. for 1.5 h, then 0.22 mol of allyl chloride was added. Then mixture was refluxed for 5 h and kept at r.t. for 24 h. The precipitate was separated by filtration and was washed with cold acetonitrile. The solvent was removed by rotary evaporation and obtained product was purified by trap to trap distillation to give colorless liquid yield 89%. H NMR (CDCl3, delta, ppm): 6.96 (m, 1H, CHF2), 5.79 (m, 1H, CH=CH2), 5.19 (t, 2H, CH2=CH-), 4.04 (d, 2H, CH2O), 3.81 (t, 2H, OCH2CF2),13C NMR (CDCl3, delta, ppm): 133.09 (CH=CH2), 118.98 (CH2=CH), 115.66 (CF2), 111.13 (CF2H), 107.77 (CF2), 104.40 (CF2), 73.55 (CH2O), 66.42 (OCH2). MS (EI, m/z): 273.3 (10.1), 272.2 (91.0) [M+], 95.0 (14.6), 84.0 (9.3), 71.1 (100), 69.1 (26.1), 57.1 (23.3), 56.1 (9.4), 51.0 (31.7).
Statistics shows that 355-80-6 is playing an increasingly important role. we look forward to future research findings about 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol.
Reference:
Article; Januszewski, Rafa?; Kownacki, Ireneusz; Maciejewski, Hieronim; Marciniec, Bogdan; Journal of Organometallic Chemistry; vol. 846; (2017); p. 263 – 268;,
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