Reference of 13674-16-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 13674-16-3 as follows.
Step 4 (2R)-2-[4-(9-Bromo-2,3-dimethyl-naphtho[2,3-b]thiophen-4-yl)-2-ethyl-phenoxy]3-phenyl-propionic acid methyl ester In a manner similar to the procedure of Example 49, Step 6 there was obtained from 4-(9-bromo-2,3-dimethyl-naphtho[2,3-b]thiophen-4-yl)-2-ethyl-phenol (0.45 g, 1.16 mmol), (S)-2-hydroxy-3-phenylpropionic acid, methyl ester (0.31 g, 1.72 mmol), triphenylphosphine (0.45 g, 1.72 mmol), diethylazodicarboxylate (0.27 mL, 1.71 mmol), and anhydrous benzene (5 mL) at 90 for 18 h the title compound as a glassy residue (0.22 g, 33%): NMR (DMSO-d6): delta8.22 (d, J=9 Hz, 1H), 7.66 (ddd, J=3, 6, 8 Hz, 1H), 7.59-7.22 (m, 7H), 7.20-7.02 (m, 2H), 6.92 (dd, J=2, 8 Hz, 1H), 5.31 (m, 1H), 3.74 and 3.70 (two s, atroph isomers, 3H), 3.32 (m, 2H), 2.64 (complex m, 2H), 2.45(s, 3H), 1.55 (s, 3H), 1.12 and 1.10 (two t, J=7 Hz, atroph isomers, 3H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13674-16-3, its application will become more common.
Reference:
Patent; American Home Products Corporation; US6251936; (2001); B1;,
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