Application of 62285-58-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 62285-58-9 as follows.
Following the general intermolecular amination procedure, 2,6-dimethylbenzyl alcohol (7q: 54 mg, 0.4 mmol), Du Bois’ catalyst (6.1 mg, 8.0 mumol), and 32 TsONHMe (0.121 g, 0.6 mmol) were stirred in TFE (4 mL) at 0 C. for 2 h. Chromatographic purification of the crude product afforded 14 (2,6-dimethyl-3-(methylamino)phenyl)methanol (8q: 28 mg, 42%) as a solid, mp 78.6 C. TLC: Rf?0.4 (40% EtOAc/hexanes); 1H NMR (400 MHz, CDCl3) delta 7.00 (d, J=8.2 Hz, 1H), 6.56 (d, J=8.2 Hz, 1H), 4.74 (s, 2H), 2.88 (s, 3H), 2.35 (s, 3H), 2.20 (s, 3H); 13C NMR (101 MHz, CDCl3) delta 145.88, 136.50, 128.53, 125.51, 121.93, 109.72, 59.77, 31.30, 19.13, 12.57. HRMS (ESI+) Calcd. for [C10H15NO+H]+ 166.1232, Found 166.1228.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,62285-58-9, its application will become more common.
Reference:
Patent; The Board of Regents of the University of Texas System; William Marsh Rice University; FALCK, John R.; PAUDYAL, Mahesh P.; KUeRTI, Laszlo; (51 pag.)US2019/152892; (2019); A1;,
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