In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 178312-48-6, name is (4,4-Difluorocyclohexyl)methanol, the common compound, a new synthetic route is introduced below. Recommanded Product: (4,4-Difluorocyclohexyl)methanol
To a solution of the crude product of the previous step (465 mg, 0.31 mmol) and triethylenediamine (0.346 mg, 0.31 mmol) cooled to 0 C. in dichloromethane (20 mL) was added a p-toluenesulfonylchloride (0.589 g, 0.31 mmol) in dichloromethane (5 mL). The reaction mixture was stirred overnight and then washed with 0.5 N HCl (20 mL). The organic layer was collected, dried over anhydrous sodium sulfate, filtered, and concentrated. The crude product was purified by flash column chromatography to give the title compound as a white solid (748 mg).
The synthetic route of 178312-48-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Theravance, Inc.; US2009/62334; (2009); A1;,
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