Some tips on 10488-69-4

Electric Literature of 10488-69-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.10488-69-4, name is Ethyl 4-chloro-3-hydroxybutanoate, molecular formula is C6H11ClO3, molecular weight is 166.6, as common compound, the synthetic route is as follows.

Example 5; [68] 41.0 g (1.084 mol) of sodium borohydride and 200 g (1.205 mol, 99.3percent ee) of ethyl (S)-4-chloro-3-hydroxybutyrate were dissolved in 400 g of tetrahydrofuran, and 34.7 g (1.084 mol) of methanol was added dropwise at room temperature for 1 hour. After stirring at room temperature for 10 hours, the reaction mixture was cooled below 1O0C. Then, after adding 122 g of 36percent HCl dropwise, the solvent was removed by distillation under reduced pressure below 4O0C. Using 550 mL of methanol, concentration under reduced pressure was performed for 3 times below 4O0C. 550 mL of di- chloromethane and 20 g of Na2SO4 were added to the resultant residue, and stirring was performed for 30 minutes. After filtering off solid inorganic materials and removing the solvent under reduced pressure, 144 g of (S)-4-chloro-l,3-butanediol was obtained as oil (yield = 96percent).

The chemical industry reduces the impact on the environment during synthesis 10488-69-4, I believe this compound will play a more active role in future production and life.

Reference:
Patent; RSTECH CORPORATION; WO2008/93955; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts