Synthetic Route of 346-06-5 ,Some common heterocyclic compound, 346-06-5, molecular formula is C8H7F3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
the [(IPr)AuCl](6mg,0.01mmol,1mol%)AgOTf2.6mg,0.01mmol,1mol%Phenylacetylene (102mg, 1mmol), 1,4- dioxane (1ml) and water (36ul, 2equiv.) Were successively added to 5ml microwave tube.After the reaction mixture was microwaved at 120 reactor for one hour, cooled to room temperature.Thereto was added [Cp * IrCl2]2(8mg, 0.01mmol, 1mol%), potassium t-butoxide (112mg, 1mmol),2-trifluoromethylbenzyl alcohol (211mg, 1.2mmol).After the reaction mixture was microwaved at 130 reactor and then reacted for 2 hours, cooled to room temperature.Filtered, and solvent was removed by rotary evaporation, then purified by column chromatography (developing solvent: petroleum ether / ethyl acetate) to give the pure title compound Yield: 84%
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,346-06-5, its application will become more common.
Reference:
Patent; Nanjing University of Science and Technology; Li, Feng; Ma, Juan; Qu, panpan; (15 pag.)CN104557500; (2016); B;,
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