Reference of 52273-77-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 52273-77-5, name is 2-(3-Aminophenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows.
N- [3- (2-HYDROXYETHYL) PHENYL]-2, 4-DIMETHYL-1, 3-THIAZOLE-5-CARBOXAMIDE; 2- (3-Aminophenyl) ethanol (1.202 g, 8.76 MMOL) was added to a solution of 2, 4-dimethyl- 1, 3-thiazole-5-carboxylic acid (1.652 g, 10.51 MMOL), 1- (3-DIMETHYLAMINOPROPYL)-3- ethylcarbodiimide hydrochloride (2.015 g, 10.51 MMOL) and 1-hydroxybenzotriazole (1.420 g, 10.51 MMOL) in dry DMF (20 mL). The mixture was stirred for 14h then the DMF was removed under reduced pressure and the residue was partitioned between DCM and saturated aqueous sodium hydrogencarbonate solution. The organic layer was dried over magnesium sulfate and concentrated under reduced pressure. The crude compound was purified by flash chromatography on silica gel, eluting with ethyl acetate-cyclohexane (1: 1 to 1: 0) affording the title compound in 73% yield (1.772 g). MS; (ES) m/z: 277 [MH+]. C14H16N202S requires 276. 1H-NMR (300 MHz, D6-DMSO) S (ppm): 9.95 (s, 1H), 7.40-7. 50 (m, 2H), 7.19 (t, 1H), 6.92 (d, 1 H), 4.60 (t, 1 H), 5.57 (dd, 2H), 2.66 (t, 2H), 2.61 (s, 3H), 2.49 (s, 3H).
According to the analysis of related databases, 52273-77-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLAXO GROUP LIMITED; WO2005/14552; (2005); A1;,
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