Related Products of 1667-12-5 , The common heterocyclic compound, 1667-12-5, name is 4,4′-Bis(hydroxymethyl)biphenyl, molecular formula is C14H14O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of 4,4?-biphenyldimethanol (3.01 g, 14 mmol) in dry THF (30 mL) at 0 was addedwith stirring under N2 a solution containing PBr3 (0.9 mL, 9.48 mmol) in dry THF (5 mL). Afterstirring for 2.5 h at room temperature, water (50 mL) was added at 0 and the solution was furtherstirred for 30 min at room tempetarure. THF was removed, and the residue was extracted into ethylacetate. This solution was washed with brine, dried over MgSO4 and evaporated. The residue waspurified by recrystallization from ethyl acetate.Yield : 89%. 1H NMR (CDCl3, 270 MHz)delta 7.56 (d, J = 8.1 Hz, 4H), 7.46 (d, J = 8.1 Hz, 4H), 4.52 (s,4H).
The synthetic route of 1667-12-5 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Sakurai, Hiroya; Arai, Tatsuo; Bulletin of the Chemical Society of Japan; vol. 89; 8; (2016); p. 911 – 913;,
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