Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 575-03-1, name is 7-Hydroxy-4-(trifluoromethyl)coumarin. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 7-Hydroxy-4-(trifluoromethyl)coumarin
General procedure: Substituted coumarin (a-e) (0.001 mol), substituted DHA (I, II)(0.001 mol) and anhydrous potassium carbonate (0.0011 mol) were added in 15 mL DMF and stirred for 5 h. After the completion of reaction, the mixture was poured in the water and extracted with ethyl acetate (50 mLx3). The organic layer was dried over anhydrous sodium sulfate and evaporated to dryness. The product was purified through column chromatography.
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Reference:
Article; Yu, Haonan; Hou, Zhuang; Tian, Ye; Mou, Yanhua; Guo, Chun; European Journal of Medicinal Chemistry; vol. 151; (2018); p. 434 – 449;,
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