Adding a certain compound to certain chemical reactions, such as: 20017-67-8, 3,3-Diphenyl-1-propanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks
To a stirred solution of difluoroacetic acid (5.00 g, 52.1 mmol) and 3,3- diphenyl-1-propanol (11.4 ml, 57.3 mmol, 1.10 eq) in diethyl ether (100 ml) is added [4-DIMETHYLAMINOPYRIDINE] (0.64 g, 5.21 mmol, 0. [01 EQ)] followed by [DIISOPROPYLCARBODIIMIDE] (6.56 g, 52.1 mmol, 1.0 [EQ).] The mixture is stirred at room temperature overnight. The precipitate is removed by vacuum filtration and washed with ether and the filtrate concentrated in vacuo. The residue is filtered through a plug of silica gel using 5% ether/hexanes eluent and the filtrate collected and concentrated. The resulting compound (14.40 g, 46.64 mmol) in xylenes (150 [ML)] is added Lawesson’s Reagent (24.1 g, 59.61 [MMOL).] The reaction mixture is heated at reflux overnight and then cooled to room temperature. A precipitate formed which is removed by vacuum filtration and washed with ethyl acetate. The filtrate is passed through a plug of silica gel and eluted with 5% ether/hexanes and concentrated to give the title compound [7. 1H NMR] (400 [MHZ),] CDC13) 8 2.47, 4.07, 4.24, 5.82, 7.23.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,20017-67-8, 3,3-Diphenyl-1-propanol, and friends who are interested can also refer to it.
Reference:
Patent; PHARMACIA & UPJOHN COMPANY; WO2004/2967; (2004); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts