Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 395-23-3, name is Phenyl(4-(trifluoromethyl)phenyl)methanol. A new synthetic method of this compound is introduced below., Application In Synthesis of Phenyl(4-(trifluoromethyl)phenyl)methanol
General procedure: A solution of 1,1-diarylmethanol, 1r-w (200mg, 0.80-1.08mmol) in dry CH2Cl2 (5mL) and TMSN3 (1.5equiv) were placed in a 25mL round-bottom flask fitted with guard tube. InBr3 (2mol%) was added to this reaction mixture. The contents were stirred at room temperature and the progress of reaction was monitored by TLC analyses. After stirring the contents for appropriate time period, the reaction was quenched with water. The product was extracted with CH2Cl2 (3¡Á15mL), washed with 10% Na2CO3 (20mL), water (20mL) and dried over anhydrous Na2SO4. The solvent was removed under reduced pressure to give brownish oil. Purification by flash chromatography afforded the products 2r-w.
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Reference:
Article; Kumar, Anil; Sharma, Ramesh K.; Singh, Tej V.; Venugopalan, Paloth; Tetrahedron; vol. 69; 50; (2013); p. 10724 – 10732;,
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