New downstream synthetic route of 23147-58-2

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,23147-58-2, its application will become more common.

Application of 23147-58-2 ,Some common heterocyclic compound, 23147-58-2, molecular formula is C4H8O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 68 (S)-N-((S)-5-((l-(2-Cyanophenyl)-lH-indazol-3-yl)methyl)-4-oxo-2,3,4,5- tetrahydrobenzo [b] [ 1 ,4]oxazepin-3 -yl)-2-(2 -hydroxyethylamino)propan amide Na(OAc)3BH (14.2 mg, 67.0 muetaiotaomicron, Eq: 1.4) was added to a solution of (S)-2-amino-N- ((S)-5-((l-(2-cyanophenyl)-lH-indazol-3-yl)methyl)-4-oxo-2,3,4,5- tetrahydrobenzo[b][l ,4]oxazepin-3-yl)propanamide (23 mg, 47.9 muetaiotaomicron, Eq: 1.00) and glycolaldehyde dimer (3.16 mg, 26.3 muetaiotaomicron, Eq: 0.55) in DCM (1.5 mL). After 72 h. at RT, the mixture was diluted with NaHC03 and extracted with DCMThecombined extracts were concentrated. The residue was purified by preparative TLC to give the title compound (16 mg, 95 %) as a solid. MS m/z 525 (MH+)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,23147-58-2, its application will become more common.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; DONNELL, Andrew F.; HAN, Xiaochun; KESTER, Robert Francis; KONG, Norman; LE, Kang; LOU, Yan; MICHOUD, Christophe; MOLITERNI, John Anthony; REMISZEWSKI, Stacy; RUPERT, Kenneth Carey; YUN, Weiya; WO2014/23708; (2014); A1;,
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