Synthetic Route of 110-73-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 110-73-6 as follows.
2-Bromothiophene (1.19 mL, 12.3 mmol, CAS 1003-09-4), copper(I) iodide (350 mg, 15 mol %), copper powder (117 mg, 15 mol %, CAS 7440-50-8) and potassium phosphate tribasic (5.22 g, 24.6 mmol) were suspended in 2-(ethylamino)ethanol (12 mL) and heated at 80 C. for 20 h under Ar. After this time, the reaction mixture was allowed to cool to room temperature and water (40 mL) added. The solution was extracted with diethyl ether (3¡Á40 mL), and the combined organic fractions washed with brine (1¡Á60 mL), dried over MgSO4 and the solvent removed in vacuo. Purification was undertaken by silica gel column chromatography (column loaded using 3% Et3N/hexane) using 2:1 hexane/ethyl acetate to elute the product as an orange oil (1.02 g, 5.96 mmol, 48%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,110-73-6, its application will become more common.
Reference:
Patent; University of Notre Dame du Lac; Smith, Bradley; US2015/5501; (2015); A1;,
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