Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5339-85-5, name is 2-(2-Aminophenyl)ethanol. A new synthetic method of this compound is introduced below., HPLC of Formula: C8H11NO
K2CO3 (0.0109 mol) and 4-(2-chloro-ethyl)-morpholine (1 HC1) (0.0036 mol) were added to a solution of 2-ethanol-aniline (0.0036 mol) in CH3CN (15 ml). The reaction was stirred at 80C for 24 hours and then cooled down to room temperature. The precipitate was filtered off and rinsed with CH3CN. The solution was concentrated under reduced pressure. The residue was purified by column chromatography over silica gel (eluent: CH2CI2/CH30H/NH40H 98/2/0. 1 ; 35-70 urn). The pure fractions were collected and the solvent was evaporated, yelding 0.7g of 2-[2-(2-morpholin-4-yl-ethylamino)-phenyl]-ethanol (77%)
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 5339-85-5, 2-(2-Aminophenyl)ethanol.
Reference:
Patent; TIBOTEC PHARMACEUTICALS LTD.; WO2005/58869; (2005); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts