Reference of 127-66-2 ,Some common heterocyclic compound, 127-66-2, molecular formula is C10H10O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: Catalyst by about 5 mg, propargylic alcohols 4.95 mmol inwater 0.5-1 mL and secondary amines by around 5 mmolwere mixed with a Schlenk tube that equipped to a stir bar.After that the apparatus was clean with carbon dioxide formore than two times, the blend was stirred under the temperatureof 50 C and pressure of 1.5 bar for carbon dioxidefor the desired time. When the considered reaction finished,the mixture was adapted by diethyl ether (3-15 mL). Theupper layers were gathered and dried by vacuuming to obtainthe crude yields that might be purified using more column chromatography onto silica gel by petroleum ether/ethylacetate (100:1-20:1).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,127-66-2, its application will become more common.
Reference:
Article; Fan, Liqun; Wang, Jinhu; Zhang, Xianman; Sadeghzadeh, Seyed Mohsen; Zhiani, Rahele; Shahroudi, Mina; Amarloo, Fatemeh; Catalysis Letters; vol. 149; 12; (2019); p. 3465 – 3475;,
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