Synthetic Route of 589-98-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 589-98-0, name is 3-Octanol, molecular formula is C8H18O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Step 3a: Synthesis of Example 54 [0268] Thionyl chloride (0.29 mL, 4 mmol) was added to a suspension of Intermediate H (0.71 G, 1.0 mmol) and benzotriazole (0.24 G, 2 mmol) in toluene/dichloromethane (1:1, 20 mL), and the obtained mixture was heated under argon at 40 C. for 1 hour. 2-Ethylhexanol was then added, and the mixture was stirred at room temperature for 3 days. The reaction mixture was poured into water (100 mL), neutralized with saturated sodium bicarbonate, stirred for 30 minutes and extracted with dichloromethane (2¡Á100 mL). The extract was dried over magnesium sulfate, the volatiles were removed under reduced pressure and the residue was chromatographed (silica gel, hexane/dichloromethane 1:2). The fractions containing a fluorescent material were combined, the solvent was evaporated and the residue was dried in a vacuum oven to provide chromophore Example 54 (661, mg, 71% yield) as an orange glassy foam. 1H NMR (400 MHz, CDCl3): delta 7.93 (d, 4H, J=8.8 Hz), 7.90 (d, 4H, J=8.8 Hz), 7.78 (s, 2H), 7.35 (dd, 4H, J=7.3 and 8.4 Hz), 7.28 (d, 4H, J=8.5 Hz), 7.22 (dd, 4H, J=1.5 and 8.8 Hz), 7.16 (tt, 2H, J=7.4 and 1.1 Hz), 7.12 (d, 4H, J=8.5 Hz), 4.20 (m, 4H), 1.69 (m, 2H), 1.44-1.30 (m, 16H), 0.94 (t, 6H, J=7.3 Hz), 0.89 (t, 6H, J=7.3 Hz). UV-vis spectrum: lambdamax=442 nm (dichloromethane), 446 nm (PVB film). Fluorimetry: lambdamax=606 nm (dichloromethane), 558 nm (PVB film).
According to the analysis of related databases, 589-98-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; NITTO DENKO CORPORATION; RACHWAL, STANISLAW; WANG, PENG; RACHWAL, BOGUMILA; ZHANG, HONGXI; YAMAMOTO, MICHIHARU; US2013/74927; (2013); A1;,
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