A new synthetic route of 3,3-Diphenyl-1-propanol

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 20017-67-8, 3,3-Diphenyl-1-propanol.

Synthetic Route of 20017-67-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 20017-67-8, name is 3,3-Diphenyl-1-propanol. This compound has unique chemical properties. The synthetic route is as follows.

Step 1. Preparation of difluoroacetic acid, O-(3,3-diphenyl-propyl) ester. [0299] Dicyclohexylcarbodiimide (12.6 g, 62.4 mmol) is added portionwise with stirring to a solution of difluoroacetic acid (4.0 g, 4.0 mL, 62.4 mmol), 3,3-diphenyl-1-propanol (14.4 g, 13.8 mL, 68.4 mol) and 4-dimethylaminopyridine (732 mg, 6.2 mmol) in ethyl ether (180 mL) at 0-5 C. The reaction mixture is allowed to warm up to r.t., and stirred at r.t. overnight. The precipitated urea by-product is filtered off and washed with excess ethyl ether. The combined filtrates are evaporated under vacuum, and the residue is purified by silica gel flash chromatography (eluent: 5% ethyl ether in hexanes). White crystalline solid (17.3 g, 96%). HPLC Rt=7.2. MS (m/z): 291 [M+H]+.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 20017-67-8, 3,3-Diphenyl-1-propanol.

Reference:
Patent; Gordeev, Mikhail F.; Renslo, Adam; Luehr, Gary W.; Lam, Stuart; Westlund, Neil E.; Patel, Dinesh V.; US2003/232812; (2003); A1;,
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