Synthetic Route of 19936-14-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 19936-14-2, name is 1-(4-Bromophenyl)cyclobutanol. This compound has unique chemical properties. The synthetic route is as follows.
To a 50 mL two-neck flask were added 1-(4-bromophenyl)cyclobutanol (80 mg, 0.35 mmol), N-(1-((1-cyanocyclopropyl)carbamoyl)cyclohexyl)-6-(4,4,5,5 -tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-2-carboxamide (168.0 mg, 0.35 mmol), Pd(dppf)Cl2¡¤CH2Cl2 (40 mg) and DMF (15 mL). To the mixture was added aqueous potassium carbonate (0.45 mL, 2 mol/L) under nitrogen protection. The resulting mixture was stirred at 90C for 3 h. To the reaction mixture was added saturated brine (50 mL), and the resulting mixture was extracted with ethyl acetate (50 mL*2). The combined organic layers were washed with saturated brine (40 mL*2), dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated in vacuo, and the residue was purified by silica-gel column chromatography (DCM:EtOAc=4:1, V/V) to give a white solid (80 mg, 50%). MS(ESI, pos.ion)m/z:498.2 (M+1); 1H NMR (600 MHz, CDCl3) delta 8.16 (s, 1H), 7.77 (d, J= 10.6 Hz, 2H), 7.67 (dd, J= 20.5, 8.3 Hz, 4H), 7.61 (d, J = 8.2 Hz, 1H), 7.54 (s, 1H), 6.61 (s, 1H), 2.69 – 2.61 (m, 2H), 2.45 (dt, J = 12.5, 9.5 Hz, 2H), 2.28 (d, J = 13.8 Hz, 2H), 2.15 – 1.98 (m, 5H), 1.82 – 1.72 (m, 4H), 1.55 (dt, J = 24.7, 9.6 Hz, 4H), 1.26 – 1.23 (m, 2H).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 19936-14-2, 1-(4-Bromophenyl)cyclobutanol.
Reference:
Patent; Sunshine Lake Pharma Co., Ltd.; WANG, Xiaojun; ZHOU, Pingjian; YANG, Chuanwen; HUANG, Changwei; XIONG, Shaohui; ZHANG, Yingjun; ZHANG, Jiancun; (139 pag.)EP3342765; (2018); A1;,
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