Extracurricular laboratory: Synthetic route of 2-Bromo-3,3,3-trifluoropropan-1-ol

At the same time, in my other blogs, there are other synthetic methods of this type of compound,311-86-4, 2-Bromo-3,3,3-trifluoropropan-1-ol, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 311-86-4, 2-Bromo-3,3,3-trifluoropropan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 2-Bromo-3,3,3-trifluoropropan-1-ol, blongs to alcohols-buliding-blocks compound. Quality Control of 2-Bromo-3,3,3-trifluoropropan-1-ol

54 g of 2-bromo-3,3,3-trifluoropropanol, 79 g of methanol, 9.7 g of activated RaneyNi catalyst and 19.3 g of potassium carbonate were charged into a 300 mL autoclave, stirred, evacuated and replaced with hydrogen After three times, pressure 5Mpa, heated to 80 C, the reaction 3.0h, stop the reaction, cooling, discharge, distillation to 3,3,3 – trifluoropropanol; Yield 95.0%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,311-86-4, 2-Bromo-3,3,3-trifluoropropan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; Xi’an Modern Chemistry Research Institute; Gu, Yujie; Lu, Jian; Ma, Hui; Wang, Zhixuan; Kang, Jianping; Du, Yongmei; Tu, Donghuai; Wan, Hong; Li, Yang; (5 pag.)CN105399607; (2016); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts