Reference of 3250-73-5 , The common heterocyclic compound, 3250-73-5, name is 2-(2-Ethoxyphenoxy)ethanol, molecular formula is C10H14O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Afterthe pyridine (200ml) was added to obtained 2 – (2- ethoxyphenoxy) ethanols (50.0g,0.274mol, 1.0eq) at 1 step and it altogether dissolved it cooled at 0. Methanesulfonyl chlorides(35.0ml, 0.453mol, 1.65eq) were dipped from the gradually to the cooledsolution and it was stirred for 1 hour while it heated to the slowly to the room temperature (20). The solid which wasgenerated after it dipped the water (350ml) as the gradually after it cooledthe above-mentioned stirred solution at 0 was filtered and 2 – (2- ethoxyphenoxy) ethylmethane sulfonate was obtained (62g, and the yield 87%). 2-(2-) NMR . Theobtained NMR peak of 2 – (2- ethoxyphenoxy) ethyl methane sulfonate showed uplike the next.
The synthetic route of 3250-73-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Boryung Pharmaceutical Co., Ltd; Kim, Ji Han; Myung, Jae Hyok; Lee, Jun Kwang; Sun, Yong Ho; Kim, Hak Do; (20 pag.)KR101525493; (2015); B1;,
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