Application of 20017-67-8, Adding some certain compound to certain chemical reactions, such as: 20017-67-8, name is 3,3-Diphenyl-1-propanol,molecular formula is C15H16O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 20017-67-8.
Step l In a round bottom flask under a nitrogen atmosphere, 3,3-Diphenylpropan-l-ol (5.0Og, 23.6 mmol) and TEA (7.15g, 70.8 mmol) were dissolved in CHCl3 (75 mL, dry). The solution was cooled with an ice-salt bath to -15C. Methane sulphonylchloride (6.72g, 59.0 mmol) was added dropwise over a period of 10 min. The solution was gradually allowed to warm to O0C and stored in the fridge at 4C overnight. The yellow/orange solution was then quenched with ice-water (ca 150 mL) and the layers were separated. The water layer was washed with CH2Cl2 (2 * 75mL), and the combined organic layers were dried (MgSO4), filtered and concentrated in vacuo at 200C. This yielded an oil that solidified upon standing (8.16g). The solid was ground, triturated with petroleum ether (50 mL) and the solid was collected by filtration (7.9Og off-white solid).
According to the analysis of related databases, 20017-67-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; KING’S COLLEGE LONDON; WO2008/87421; (2008); A2;,
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