The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2566-44-1, name is 2-Cyclopropylethanol. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C5H10O
To a solution of triphosgene (68 mg, 0.23 mmol) in dichloromethane (0.5 mL) was added 2-cyclopropylethanol (69 mg, 0.80 mmol). After the solution was stirred for 45 min at ambient temperature N,N-diisopropyl ethyl amine (156 mul, 0.912 mmol) and rac-{4-[(3S,4R)-3-(3,4-dichloro-phenyl)-4-methylamino-pyrrolidine-1-carbonyl]-piperidin-1-yl}-(1-methyl-cyclopropyl)-methanone (50 mg, 0.11 mmol) were added and the solution was stirred for 3 d at ambient temperature. It was diluted with ethyl acetate (15 mL) and washed with aqueous sodium carbonate (1 M, 15 mL) and brine (15 mL). The aqueous layers were extracted with ethyl acetate, dried over sodium sulfate and concentrated. Purification by chromatography (SiO2, ethyl acetate_methanol=100:0 to 80:20) afforded the title compound (59 mg, 94%) as an off-white foam. MS m/e: 550.3 [M]+.
With the rapid development of chemical substances, we look forward to future research findings about 2566-44-1.
Reference:
Patent; Knust, Henner; Koblet, Andreas; Nettekoven, Matthias; Ratni, Hasane; Riemer, Claus; Vifian, Walter; US2011/144081; (2011); A1;,
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