Synthetic Route of 100751-63-1 , The common heterocyclic compound, 100751-63-1, name is 6-Bromo-2-naphthylmethanol, molecular formula is C11H9BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
(6-bromo-naphthalen-2-yl)-methanol (0.307 g, 1.29 mmol) obtained in Preparation Example 102 was dissolvedin 5 mL of acetonitrile. Thionyl-chloride (0.188 mL, 2.59 mmol) was added thereto at 0C, and the mixture was stirredat room temperature for 1 hour. The reaction solution was distilled under reduced pressure and purified by columnchromatography to obtain the title compound (0.248 g, 75%).1H-NMR (CDCl3) delta 8.00 (1H, s), 7.83-7.68 (3H, m), 7.58-7.53 (2H, m), 4.73 (2H, s).
The synthetic route of 100751-63-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; LG Chem, Ltd.; KIM, Young Kwan; PARK, Sang Yun; JOO, Hyun Woo; CHOI, Eun Sil; PAEK, Seung Yup; KANG, Seung Wan; KIM, Byung Gyu; LEE, Chang Seok; KIM, Sung Wook; LEE, Sang Dae; (369 pag.)EP3239143; (2017); A2;,
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