New downstream synthetic route of 67853-03-6

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 67853-03-6, Methyl 3-(hydroxymethyl)benzoate, other downstream synthetic routes, hurry up and to see.

Related Products of 67853-03-6 ,Some common heterocyclic compound, 67853-03-6, molecular formula is C9H10O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 163 (23.0 g, 138 mmol) in THF (300 mL) was added NaH (8.3 g, 207 mmol) at 0 C. Then the mixture was stirred at 25 C. for 30 min. Then CH3I (72.5 g, 511 mmol) was added dropwise and the mixture was stirred at 25 C. for 3 h. The mixture was quenched with HCl (1M) (240 mL) at 0 C. The reaction mixture was combined with a second reaction and extracted with EA (3¡Á400 mL). The organic phase was washed with brine, dried over anhydrous Na2SO4, filtered and concentrated under vacuum to the residue. The residue was purified by column (PE:EA=10:1 to 5:1) to afford 164 as yellow oil (12.0 g, 53% yield, 88% purity). [M+H]+ calcd for C10H12O3 181.09 found 181.3.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 67853-03-6, Methyl 3-(hydroxymethyl)benzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THERAVANCE BIOPHARMA R&D IP, LLC; Kulyk, Svitlana; Owens, Christina; Sullivan, Steven D.E.; Kozak, Jennifer; Hughes, Adam D.; (248 pag.)US2020/188370; (2020); A1;,
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