Electric Literature of 629-30-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.629-30-1, name is 1,7-Heptanediol, molecular formula is C7H16O2, molecular weight is 132.2, as common compound, the synthetic route is as follows.
To a solution of 1,7- heptane diol (10.0 g, 75.7 mmol) in THF (100 mL) was added sodium hydride (1.81 g, 60percent dispersion in oil, 75.7 mmol) portion wise at 0 oC under nitrogen atmosphere. Stir the reaction mixture at 0 oC for 15 min. Then TBDPSCl (20.8 g, 75.7 mmol) was added slowly to the reaction mixture followed by addition of TBAI (2.79 g, 7.57 mmol). The stirring was continued for additional 12 h at room temperature. The reaction mixture was quenched at 0 oC by saturated aqueous NH4Cl solution (200 mL). THF was removed under reduced pressure and the product was extracted from aqueous layer with EtOAc (3 x 500 mL).The combined organic layers were washed with brine (2 x 100 mL) and dried over Na2SO4(anhydrous), filtered and concentrated in vacuo. Purification by column chromatography (Silica gel) of crude residue eluting with 30-35percent EtOAc in hexane afforded mono-protected alcohol as a colorless oil. Yield : 25.1 g, 89 percent 1H NMR (400 MHz, CDCl3) : d 7.64-7.61 (m, 4H), 7.38-7.31 (m, 6H), 3.66-3.56 (m, 4H), 1.58-1.48 (m, 3H), 1.41-1.25 (m, 7H), 1.04 (s, 9H).
The chemical industry reduces the impact on the environment during synthesis 629-30-1, I believe this compound will play a more active role in future production and life.
Reference:
Article; Kumaraswamy, Gullapalli; Ramakrishna, Gajula; Sridhar, Balasubramanian; Tetrahedron Letters; vol. 52; 15; (2011); p. 1778 – 1782;,
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