Electric Literature of 39895-56-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 39895-56-2 as follows.
To a mixture of 4-pyrrolidin-1-ylbenzoic acid (2.0 g, 10.5 mmol), (4- aminomethylphenyl) methanol (4.3 g, 31.4 mmol), 1-hydroxybenzotriazole (1.7 g, 12.6 mmol), and DMAP (256 mg, 2.1 mmol) in pyridine (50 mL) was added EDC (3.0 g, 15.7 mmol), and the mixture was stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure, and an aqueous NaHCO3 solution (50 mL) was added. The mixture was extracted with 5% MeOH in CHC13 (150 mL x 2), and the organic layer was dried (MgS04) and evaporated under reduced pressure. The crude product was purified by MPLC on silica gel (3% MeOH in CHC13) to afford the titled compound (2.56 g, 79%) as a white solid. H NMR (DMSO-d6) 8 1.96 (m, 4H), 3.28 (m, 4H), 4.41-4. 47 (m, 4H), 5.10 (t, 1H, J= 5.7 Hz), 6.53 (m, 2H), 7.25 (apparent s, 4H), 7.75 (m, 2H), 8. 59 (br t, 1H, J=6.0 Hz)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,39895-56-2, its application will become more common.
Reference:
Patent; SK CHEMICALS, CO., LTD.; IN2GEN CO., LTD.; WO2003/87066; (2003); A1;,
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