Related Products of 445-26-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 445-26-1, name is 1-(2-Fluorophenyl)ethanol. A new synthetic method of this compound is introduced below.
To a solution of ethyl 2-fluoro-4-iodonicotinate (0.70 g) obtained by a known method (Organic Letters, 7(10), 1943-1946; 2005) and 1-(2-fluorophenyl)ethanol (0.50 g) in THF (7 mL) was added 60% sodium hydride (0.14 g) at 0C, and the mixture was stirred at the same temperature for 1 hr. To the reaction solution was added water at 0C, and the mixture was diluted with ethyl acetate. The organic layer was separated, washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated. The residue was purified by silica gel chromatography (hexane-ethyl acetate) to give the title compound (0.77 g). 1H NMR (300 MHz, CDCl3) delta 1.42 (3H, t, J = 7.1 Hz), 1.61 (3H, d, J = 6.6 Hz), 4.47 (2H, q, J = 7.2 Hz), 6.48 (1H, q, J = 6.5 Hz), 6.94-7.14 (2H, m), 7.17-7.24 (1H, m), 7.25-7.30 (1H, m), 7.41 (1H, td, J = 7.5, 1.6 Hz), 7.73 (1H, d, J = 5.5 Hz).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,445-26-1, 1-(2-Fluorophenyl)ethanol, and friends who are interested can also refer to it.
Reference:
Patent; Takeda Pharmaceutical Company Limited; SUGIMOTO, Takahiro; NAKAMURA, Minoru; SAKAMOTO, Hiroki; SUZUKI, Shinkichi; YAMADA, Masami; KAMATA, Makoto; KOJIMA, Takuto; FUJIMORI, Ikuo; SHIMOKAWA, Kenichiro; EP2921480; (2015); A1;,
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