Related Products of 56456-49-6 ,Some common heterocyclic compound, 56456-49-6, molecular formula is C7H6ClFO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of 2,3,5-trifluoropyridine (1.5 g, 11 mmol) and 4-chloro-2-fluorobenzyl alcohol (1.81 g, 11.3 mmol) in NMP (20 mL) was added K2CO3 (4.67 g, 33.8 mmol) at 25 C. and the mixture was stirred at 100 C. for 16 h. The mixture was poured into water (30 mL) and then extracted with EtOAc (3*50 mL). The combined organic extracts were washed with brine (3*40 mL), dried over Na2SO4, filtered and concentrated under reduced pressure. The crude product was purified by flash chromatography (0 to 5% EtOAc/PE gradient) to give 2-((4-chloro-2-fluorobenzyl)oxy)-3,6-difluoropyridine (2.45 g, 80%) as a colorless oil. 1H NMR (CDCl3) delta 7.41-7.54 (m, 2H), 7.11-7.20 (m, 2H), 6.47 (ddd, 1H), 5.44 (s, 2H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 56456-49-6, 4-Chloro-2-fluorobenzyl alcohol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Pfizer Inc.; Aspnes, Gary Erik; Bagley, Scott W.; Curto, John M.; Dowling, Matthew S.; Edmonds, David; Flanagan, Mark E.; Futatsugi, Kentaro; Griffith, David A.; Huard, Kim; Ingle, Gajendra; Jiao, Wenhua; Limberakis, Chris; Mathiowetz, Alan M.; Piotrowski, David W.; Ruggeri, Roger B.; (73 pag.)US2018/170908; (2018); A1;,
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