Application of 932-01-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.932-01-4, name is 4,4-Dimethylcyclohexanol, molecular formula is C8H16O, molecular weight is 128.21, as common compound, the synthetic route is as follows.
Method B: To a solution of 7-nitrophthalazin-l(2H)-one (Intermediate- 10, step-1 , 355 mg, 1.858 mmol) and 4,4-dimethylcyclohexanol (356 mg, 2.78 mmol) in THF (6 mL) were added PPh3 (1.22 g, 4.64 mmol) and diisopropyl azodicarboxylate (1.12 g, 5.57 mmol) and the reaction mixture was heated at reflux for 4 h. Then the reaction mixture was quenched with water and was extracted with EtOAc. The organic layer was washed with brine, separated, dried, filtered and concentrated. The residue was purified by column chromatography to afford 300 mg of the title product.
The chemical industry reduces the impact on the environment during synthesis 932-01-4, I believe this compound will play a more active role in future production and life.
Reference:
Patent; GLENMARK PHARMACEUTICALS S.A.; GHARAT, Laxmikant Atmaram; BANERJEE, Abhisek; KHAIRATKAR-JOSHI, Neelima; KATTIGE, Vidya Ganapati; WO2013/72825; (2013); A1;,
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