Synthetic Route of 41175-50-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 41175-50-2 as follows.
(Z)-/V-(11 -methyl-2, 3,6, 7-tetrahydro-1H,5H,12H-quinolizino[1,9-bc]phenoxazin-12- ylidene)ethanaminium (LGW-01-99). Compound 26 (50 mg, 0.26 mmol) was dissolved in a solution of /-PrOH/H20 (9/1 , 1 mL) at 80 C for 30 min. A suspended solution of 7 (50 mg, 0.27 mmol) and HCIO4 (70%, 30 m) in 90% /-PrOH (2 mL) was added in 4 portions over 1 h. The resulting solution was stirred overnight. After which, the dark blue solution was evaporated under reduced pressure, and the residue was purified on a Biotage Isolera Flash System using SNAP Ultra cartridge with a mobile phase of CHCI3 and MeOH containing 0.5% formic acid (gradient, 2-15% of MeOH in CHC ). The fractions containing product were pooled and evaporated, affording LGW-01-99 (33 mg, 33%) as a dark blue solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,41175-50-2, its application will become more common.
Reference:
Patent; OREGON HEALTH & SCIENCE UNIVERSITY; OREGON STATE UNIVERSITY; GIBBS, Summer L.; BARTH, Connor W.; ALANI, Wathah G.; SHAH, Vidhiben; WANG, Lei; (167 pag.)WO2020/33435; (2020); A1;,
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